Literature DB >> 2222535

Binding of anti-DNA antibodies and inhibition of glomerulonephritis in MRL-lpr/lpr mice by heparin.

Y Naparstek1, A Ben-Yehuda, M P Madaio, R Bar-Tana, L Schuger, G Pizov, Z V Neeman, I R Cohen.   

Abstract

Heparin was found to inhibit the DNA binding of antibodies eluted from kidneys of both humans and MRL-lpr/lpr mice with systemic lupus erythematosus. Treatment of MRL-lpr/lpr mice with low doses of heparin significantly inhibited renal damage. These results suggest that low-dose heparin might be useful in preventing renal damage in patients with lupus nephritis.

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Year:  1990        PMID： 2222535     DOI： 10.1002/art.1780331013

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  14 in total

Review 1.  Anti-DNA antibodies. Their idiotypes and SLE.

Authors:  D Buskila; Y Shoenfeld
Journal:  Clin Rev Allergy       Date:  1994

2.  Peptide inhibition of glomerular deposition of an anti-DNA antibody.

Authors:  B Gaynor; C Putterman; P Valadon; L Spatz; M D Scharff; B Diamond
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-04       Impact factor: 11.205

3.  Heparin prevents intracellular hyaluronan synthesis and autophagy responses in hyperglycemic dividing mesangial cells and activates synthesis of an extensive extracellular monocyte-adhesive hyaluronan matrix after completing cell division.

Authors:  Aimin Wang; Juan Ren; Christina P Wang; Vincent C Hascall
Journal:  J Biol Chem       Date:  2014-01-30       Impact factor: 5.157

Review 4.  B cells and autoantibodies in the pathogenesis of lupus nephritis.

Authors:  M P Madaio
Journal:  Immunol Res       Date:  1998       Impact factor: 2.829

5.  Extracorporeal immunoadsorption of antibodies against the VRT-101 laminin epitope in systemic lupus erythematosus: a feasibility evaluation study.

Authors:  Alon Y Hershko; Anat Scheiman-Elazari; Suhail Aamar; Yaakov Naparstek
Journal:  Immunol Res       Date:  2013-07       Impact factor: 2.829

Review 6.  The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?

Authors:  Beatrice Goilav; Chaim Putterman
Journal:  Semin Nephrol       Date:  2015-09       Impact factor: 5.299

7.  Higher anti-heparan sulphate reactivity during systemic lupus erythematosus (SLE) disease exacerbations with renal manifestations; a long term prospective analysis.

Authors:  C Kramers; R M Termaat; E J ter Borg; M C van Bruggen; C G Kallenberg; J H Berden
Journal:  Clin Exp Immunol       Date:  1993-07       Impact factor: 4.330

8.  Nephritogenicity of the lprcg gene on the MRL background.

Authors:  M Kimura; Y Ogata; K Shimada; T Wakabayashi; H Onoda; T Katagiri; A Matsuzawa
Journal:  Immunology       Date:  1992-07       Impact factor: 7.397

9.  Decrease of heparan sulfate staining in the glomerular basement membrane in murine lupus nephritis.

Authors:  M C van Bruggen; K Kramers; M N Hylkema; J van den Born; M A Bakker; K J Assmann; R J Smeenk; J H Berden
Journal:  Am J Pathol       Date:  1995-03       Impact factor: 4.307

10.  The double edged sword of the immune response: mutational analysis of a murine anti-pneumococcal, anti-DNA antibody.

Authors:  C Putterman; W Limpanasithikul; M Edelman; B Diamond
Journal:  J Clin Invest       Date:  1996-05-15       Impact factor: 14.808
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