Literature DB >> 22224640

Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis.

Roy Pettipher1, Mark Whittaker.   

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Year:  2012        PMID： 22224640     DOI： 10.1021/jm2013997

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  11 in total

Review 1.  G Protein-Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action.

Authors:  Stacy Gelhaus Wendell; Hao Fan; Cheng Zhang
Journal:  Pharmacol Rev       Date:  2020-01       Impact factor: 25.468

2.  Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma.

Authors:  J A Schmidt; F M Bell; E Akam; C Marshall; I A Dainty; A Heinemann; I G Dougall; R V Bonnert; C A Sargent
Journal:  Br J Pharmacol       Date:  2013-04       Impact factor: 8.739

Review 3.  Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function.

Authors:  Joseph M Kulinski; Rosa Muñoz-Cano; Ana Olivera
Journal:  Eur J Pharmacol       Date:  2015-05-02       Impact factor: 4.432

4.  Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma.

Authors:  Xianhai Huang; Jason Brubaker; Wei Zhou; Purakkattle J Biju; Li Xiao; Ning Shao; Ying Huang; Li Dong; Zhidan Liu; Rema Bitar; Alexei Buevich; Joon Jung; Scott L Peterson; John W Butcher; Joshua Close; Michelle Martinez; Rachel N MacCoss; Hongjun Zhang; Scott Crawford; Kevin D McCormick; Robert Aslanian; Ravi Nargund; Craig Correll; Francois Gervais; Hongchen Qiu; Xiaoxin Yang; Charles Garlisi; Diane Rindgen; Kevin M Maloney; Phieng Siliphaivanh; Anandan Palani
Journal:  ACS Med Chem Lett       Date:  2018-06-23       Impact factor: 4.345

5.  Structures of the Human PGD2 Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition.

Authors:  Lei Wang; Dandan Yao; R N V Krishna Deepak; Heng Liu; Qingpin Xiao; Hao Fan; Weimin Gong; Zhiyi Wei; Cheng Zhang
Journal:  Mol Cell       Date:  2018-09-13       Impact factor: 17.970

6.  The prostaglandin D₂ receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung.

Authors:  E D Tait Wojno; L A Monticelli; S V Tran; T Alenghat; L C Osborne; J J Thome; C Willis; A Budelsky; D L Farber; D Artis
Journal:  Mucosal Immunol       Date:  2015-04-08       Impact factor: 7.313

Review 7.  Emerging concepts and future challenges in innate lymphoid cell biology.

Authors:  Elia D Tait Wojno; David Artis
Journal:  J Exp Med       Date:  2016-10-10       Impact factor: 14.307

Review 8.  Eicosanoid Control Over Antigen Presenting Cells in Asthma.

Authors:  Nincy Debeuf; Bart N Lambrecht
Journal:  Front Immunol       Date:  2018-09-04       Impact factor: 7.561

Review 9.  Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease.

Authors:  Leena George; Christopher E Brightling
Journal:  Ther Adv Chronic Dis       Date:  2016-01       Impact factor: 5.091

10.  Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44.

Authors:  Amanda M Nelson; Dorothy E Loy; John A Lawson; Adiya S Katseff; Garret A Fitzgerald; Luis A Garza
Journal:  J Invest Dermatol       Date:  2012-11-29       Impact factor: 8.551
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