Literature DB >> 2222450

Stimulation of Mn-superoxide dismutase expression by tumor necrosis factor-alpha: quantitative determination of Mn-SOD protein levels in TNF-resistant and sensitive cells by ELISA.

T Kawaguchi1, A Takeyasu, K Matsunobu, T Uda, M Ishizawa, K Suzuki, T Nishiura, M Ishikawa, N Taniguchi.   

Abstract

Marked increase in protein levels of Mn-superoxide dismutase (Mn-SOD) was found in TNF-resistant cell lines after treatment with Tumor Necrosis Factor (TNF). No such increase was observed in Cu,Zn-superoxide dismutase (Cu, Zn-SOD) protein in either TNF-resistant or sensitive cells. These results support the data that the Mn-SOD is one of the rescue proteins required for resistance to TNF cytotoxicity in these cell lines (Wong et al., Cell 58, 923-931, 1990). Mn-SOD was also responsive to TNF stimulation in KURAMOCHI, a human ovarian adenocarcinoma cell line. This may explain our previous result that Mn-SOD protein is highly expressed in epithelial ovarian cancer (Ishikawa et al. Cancer Res. 50, 2538-2542, 1990).

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Year:  1990        PMID： 2222450     DOI： 10.1016/0006-291x(90)90838-e

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

1.  Hepatic response to the oxidative stress induced by E. coli endotoxin: glutathione as an index of the acute phase during the endotoxic shock.

Authors:  M T Portolés; M Catalá; A Antón; R Pagani
Journal:  Mol Cell Biochem       Date:  1996-06-21       Impact factor: 3.396

2.  Induction of manganese superoxide dismutase mRNA by okadaic acid and protein synthesis inhibitors.

Authors:  J Fujii; T Nakata; E Miyoshi; Y Ikeda; N Taniguchi
Journal:  Biochem J       Date:  1994-07-01       Impact factor: 3.857

3.  Responses of human glioblastoma cells to human natural tumor necrosis factor-alpha: susceptibility, mechanism of resistance and cytokine production studies.

Authors:  S Sakuma; Y Sawamura; M Tada; T Aida; H Abe; K Suzuki; N Taniguchi
Journal:  J Neurooncol       Date:  1993-03       Impact factor: 4.130

4.  An immunohistochemical study of the neuronal expression of manganese superoxide dismutase in sporadic amyotrophic lateral sclerosis.

Authors:  M Wakai; K Mokuno; Y Hashizume; K Kato
Journal:  Acta Neuropathol       Date:  1994       Impact factor: 17.088

5.  Immunohistochemical expression of manganese superoxide dismutase in hepatocellular carcinoma, using a specific monoclonal antibody.

Authors:  Y Aida; S Maeyama; T Takakuwa; T Uchikoshi; Y Endo; K Suzuki; N Taniguchi
Journal:  J Gastroenterol       Date:  1994-08       Impact factor: 7.527
  5 in total

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