Literature DB >> 2222443

Binding of human sex hormone-binding globulin-androgen complexes to the placental syncytiotrophoblast membrane.

N I Krupenko1, G V Avvakumov, O A Strel'chyonok.   

Abstract

We have found that human SHBG complexed with androgens binds specifically to the plasma membrane of human placental syncytiotrophoblast. Apparent equilibrium association constants were 5.3.10(11) M-1 for SHBG-testosterone complex and 1.1.10(11) M-1 for SHBG-5 alpha-dihydrotestosterone. Devoid of steroid, SHBG did not bind to the membrane. This suggests that the specific membrane binding of SHBG-androgen complexes is a step of the mechanism of androgen action on syncytiotrophoblast.

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Year:  1990        PMID： 2222443     DOI： 10.1016/0006-291x(90)90824-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  3 in total

Review 1.  Sex hormone-binding globulin: not only a transport protein. What news is around the corner?

Authors:  N Fortunati
Journal:  J Endocrinol Invest       Date:  1999-03       Impact factor: 4.256

2.  The membrane receptor for sex steroid binding protein is not ubiquitous.

Authors:  R Frairia; N Fortunati; F Fissore; A Fazzari; P Zeppegno; L Varvello; M Orsello; L Berta
Journal:  J Endocrinol Invest       Date:  1992-09       Impact factor: 4.256

3.  Sex hormone-binding globulin provides a novel entry pathway for estradiol and influences subsequent signaling in lymphocytes via membrane receptor.

Authors:  Andrea Balogh; Eva Karpati; Andrea E Schneider; Szabolcs Hetey; Andras Szilagyi; Kata Juhasz; Gloria Laszlo; Petronella Hupuczi; Peter Zavodszky; Zoltan Papp; Janos Matko; Nandor Gabor Than
Journal:  Sci Rep       Date:  2019-01-09       Impact factor: 4.379
  3 in total

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