Literature DB >> 22224285

Cytotoxic activity and cell cycle analysis of hexahydrocurcumin on SW 480 human colorectal cancer cells.

Chung-Yi Chen1, Woei-Ling Yang, Soong-Yu Kuo.   

Abstract

The cytotoxicity of hexahydrocurcumin and its effect on the cell cycle in human colorectal cancer cells SW480 has been studied for the first time. The compound, extracted from Zingiber officinale, was shown to be cytotoxic to colorectal cancer cells. Treatment of SW480 cells with hexahydrocurcumin (100 microM) resulted in a massive accumulation of the cells in the G1/G0 phase of the cell cycle. The cytotoxic effect of hexahydrocurcumin may prove useful in cancer prevention.

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Year:  2011        PMID： 22224285

Source DB:  PubMed          Journal:  Nat Prod Commun        ISSN： 1555-9475            Impact factor:   0.986


  10 in total

Review 1.  The role and place of medicinal plants in the strategies for disease prevention.

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Journal:  Afr J Tradit Complement Altern Med       Date:  2013-08-12

Review 2.  Bringing Curcumin to the Clinic in Cancer Prevention: a Review of Strategies to Enhance Bioavailability and Efficacy.

Authors:  Rama I Mahran; Magda M Hagras; Duxin Sun; Dean E Brenner
Journal:  AAPS J       Date:  2016-10-25       Impact factor: 4.009

Review 3.  Perspectives on new synthetic curcumin analogs and their potential anticancer properties.

Authors:  Alok Vyas; Prasad Dandawate; Subhash Padhye; Aamir Ahmad; Fazlul Sarkar
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.116

Review 4.  Ginger and its constituents: role in prevention and treatment of gastrointestinal cancer.

Authors:  Sahdeo Prasad; Amit K Tyagi
Journal:  Gastroenterol Res Pract       Date:  2015-03-08       Impact factor: 2.260

5.  Curcumin-Free Turmeric Exhibits Activity against Human HCT-116 Colon Tumor Xenograft: Comparison with Curcumin and Whole Turmeric.

Authors:  Sahdeo Prasad; Amit K Tyagi; Zahid H Siddik; Bharat B Aggarwal
Journal:  Front Pharmacol       Date:  2017-12-12       Impact factor: 5.810

6.  Acute and subchronic oral toxicity studies of hydrogenated curcuminoid formulation 'CuroWhite' in rats.

Authors:  Sreeraj Gopi; Joby Jacob; Kotrappa Y Mathur
Journal:  Toxicol Rep       Date:  2016-10-25

Review 7.  Formulation of More Efficacious Curcumin Delivery Systems Using Colloid Science: Enhanced Solubility, Stability, and Bioavailability.

Authors:  Bingjing Zheng; David Julian McClements
Journal:  Molecules       Date:  2020-06-17       Impact factor: 4.411

8.  Synthesis and evaluation of novel 1-(((6-substitutedbenzo[d]thiazol-2-yl)amino)(heteroaryl)methyl)naphthalen-2-ol as pesticidal agents.

Authors:  Junfeng Shang; Yuxin Li; Na Yang; Lixia Xiong; Baolei Wang
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

Review 9.  Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice.

Authors:  Sahdeo Prasad; Amit K Tyagi; Bharat B Aggarwal
Journal:  Cancer Res Treat       Date:  2014-01-15       Impact factor: 4.679

10.  Disposition, Metabolism and Histone Deacetylase and Acetyltransferase Inhibition Activity of Tetrahydrocurcumin and Other Curcuminoids.

Authors:  Júlia T Novaes; Ryan Lillico; Casey L Sayre; Kalyanam Nagabushnam; Muhammed Majeed; Yufei Chen; Emmanuel A Ho; Ana Luísa de P Oliveira; Stephanie E Martinez; Samaa Alrushaid; Neal M Davies; Ted M Lakowski
Journal:  Pharmaceutics       Date:  2017-10-12       Impact factor: 6.321
  10 in total

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