Literature DB >> 2222418

Effect of local anaesthetics on mitochondrial membrane potential in living cells.

M Grouselle1, O Tueux, P Dabadie, D Georgescaud, J P Mazat.   

Abstract

Using the laser dye rhodamine 123, we demonstrated that local anaesthetics can reach mitochondria in cell culture and reversibly decrease, or even collapse, their transmembrane potential. This effect is highly dependent on the lipid-solubility of the local anaesthetic and can be facilitated by the presence of a lipophilic anion.

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Year:  1990        PMID： 2222418      PMCID： PMC1149544          DOI： 10.1042/bj2710269

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  10 in total

Review 1.  Mitochondrial membrane potential in living cells.

Authors:  L B Chen
Journal:  Annu Rev Cell Biol       Date:  1988

2.  Uncoupling effects of local anesthetics on rat liver mitochondria.

Authors:  P Dabadie; P Bendriss; P Erny; J P Mazat
Journal:  FEBS Lett       Date:  1987-12-21       Impact factor: 4.124

3.  Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties.

Authors:  R K Emaus; R Grunwald; J J Lemasters
Journal:  Biochim Biophys Acta       Date:  1986-07-23

4.  Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

Authors:  B Hille
Journal:  J Gen Physiol       Date:  1977-04       Impact factor: 4.086

5.  Further studies on F1-ATPase inhibition by local anesthetics.

Authors:  B Chazotte; G Vanderkooi; D Chignell
Journal:  Biochim Biophys Acta       Date:  1982-06-18

6.  Localization of mitochondria in living cells with rhodamine 123.

Authors:  L V Johnson; M L Walsh; L B Chen
Journal:  Proc Natl Acad Sci U S A       Date:  1980-02       Impact factor: 11.205

7.  Probing mitochondria in living cells with rhodamine 123.

Authors:  L B Chen; I C Summerhayes; L V Johnson; M L Walsh; S D Bernal; T J Lampidis
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1982

8.  The effect of butacaine on adenine nucleotide binding and translocation in rat liver mitochondria.

Authors:  D R Fayle; G J Barritt; F L Bygrave
Journal:  Biochem J       Date:  1975-06       Impact factor: 3.857

9.  Studies on the mechanism of uncoupling by amine local anesthetics. Evidence for mitochondrial proton transport mediated by lipophilic ion pairs.

Authors:  K D Garlid; R A Nakashima
Journal:  J Biol Chem       Date:  1983-07-10       Impact factor: 5.157

10.  Multiple sites of inhibition of mitochondrial electron transport by local anesthetics.

Authors:  B Chazotte; G Vanderkooi
Journal:  Biochim Biophys Acta       Date:  1981-07
  10 in total
  11 in total

1.  An evaluation of the delayed effect of intra-articular injections of lidocaine (2%) on articular cartilage: an experimental study in rabbits.

Authors:  Hamidreza Yazdi; Bahahreh Tabatabaeian Nimavard; Mohammadali Shokrgozar; Mohammadmehdi Dehghan; Reza Jamei Moayedi; Mohammad Majidi; Tahmineh Mokhtari
Journal:  Eur J Orthop Surg Traumatol       Date:  2014-12

2.  Lidocaine cytotoxicity to the bovine articular chondrocytes in vitro: changes in cell viability and proteoglycan metabolism.

Authors:  Tsuyoshi Miyazaki; Shigeru Kobayashi; Kenichi Takeno; Takafumi Yayama; Adam Meir; Hisatoshi Baba
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2011-01-13       Impact factor: 4.342

3.  Mitochondrial potential (ΔΨm) changes in single rat hepatocytes: the effect of orthovanadate nanoparticles doped with rare-earth elements.

Authors:  Nataliya S Kavok; Katherine A Averchenko; Vladimir K Klochkov; Svetlana L Yefimova; Yuri V Malyukin
Journal:  Eur Phys J E Soft Matter       Date:  2014-12-24       Impact factor: 1.890

4.  Do local anesthetics interact preferentially with membrane lipid rafts? Comparative interactivities with raft-like membranes.

Authors:  Hironori Tsuchiya; Takahiro Ueno; Maki Mizogami; Ko Takakura
Journal:  J Anesth       Date:  2010-04-23       Impact factor: 2.078

5.  Local anesthetics induce apoptosis in human thyroid cancer cells through the mitogen-activated protein kinase pathway.

Authors:  Yuan-Ching Chang; Yi-Chiung Hsu; Chien-Liang Liu; Shih-Yuan Huang; Meng-Chun Hu; Shih-Ping Cheng
Journal:  PLoS One       Date:  2014-02-21       Impact factor: 3.240

6.  Modulation of mitochondrial bioenergetics in the isolated Guinea pig beating heart by potassium and lidocaine cardioplegia: implications for cardioprotection.

Authors:  Mohammed Aldakkak; David F Stowe; Edward J Lesnefsky; James S Heisner; Qun Chen; Amadou K S Camara
Journal:  J Cardiovasc Pharmacol       Date:  2009-10       Impact factor: 3.105

7.  HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death.

Authors:  Akihisa Okamoto; Chisato Sumi; Hiromasa Tanaka; Munenori Kusunoki; Teppei Iwai; Kenichiro Nishi; Yoshiyuki Matsuo; Hiroshi Harada; Keizo Takenaga; Hidemasa Bono; Kiichi Hirota
Journal:  Sci Rep       Date:  2017-06-19       Impact factor: 4.379

8.  Cytotoxicity of local anesthetics on rabbit adipose-derived mesenchymal stem cells during early chondrogenic differentiation.

Authors:  Tao Wu; Zhaohong Shi; Haixin Song; Yangzheng Li; Jian-Hua Li
Journal:  Exp Ther Med       Date:  2018-07-30       Impact factor: 2.447

9.  The effects of an insulin-glucose-potassium (IGK) pretreatment on the bupivacaine cardiotoxicity.

Authors:  Jin-Tae Kim; Sol-Mon Yang; Kook Hyun Lee
Journal:  Korean J Anesthesiol       Date:  2013-01-21

10.  Levobupivacaine inhibits proliferation and promotes apoptosis of breast cancer cells by suppressing the PI3K/Akt/mTOR signalling pathway.

Authors:  Akosua Kotaa Kwakye; Sylvanus Kampo; Jiaxin Lv; Muhammad Noman Ramzan; Seidu A Richard; Aglais Arredondo Falagán; Jerry Agudogo; Evans Atito-Narh; Qiu Yan; Qing-Ping Wen
Journal:  BMC Res Notes       Date:  2020-08-17
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