Literature DB >> 22223806

Dystroglycan function requires xylosyl- and glucuronyltransferase activities of LARGE.

Kei-ichiro Inamori1, Takako Yoshida-Moriguchi, Yuji Hara, Mary E Anderson, Liping Yu, Kevin P Campbell.   

Abstract

Posttranslational modification of alpha-dystroglycan (α-DG) by the like-acetylglucosaminyltransferase (LARGE) is required for it to function as an extracellular matrix (ECM) receptor. Mutations in the LARGE gene have been identified in congenital muscular dystrophy patients with brain abnormalities. However, the precise function of LARGE remains unclear. Here we found that LARGE could act as a bifunctional glycosyltransferase, with both xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-α1,3-glucuronic acid-β1-]. This modification allowed α-DG to bind laminin-G domain-containing ECM ligands.

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Year:  2012        PMID： 22223806      PMCID： PMC3702376          DOI： 10.1126/science.1214115

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  17 in total

1.  The crystal structure of a laminin G-like module reveals the molecular basis of alpha-dystroglycan binding to laminins, perlecan, and agrin.

Authors:  E Hohenester; D Tisi; J F Talts; R Timpl
Journal:  Mol Cell       Date:  1999-11       Impact factor: 17.970

Review 2.  Dystroglycan: from biosynthesis to pathogenesis of human disease.

Authors:  Rita Barresi; Kevin P Campbell
Journal:  J Cell Sci       Date:  2006-01-15       Impact factor: 5.285

3.  Enhanced laminin binding by alpha-dystroglycan after enzymatic deglycosylation.

Authors:  Ariana C Combs; James M Ervasti
Journal:  Biochem J       Date:  2005-08-15       Impact factor: 3.857

Review 4.  Dystroglycanopathies: coming into focus.

Authors:  Caroline Godfrey; A Reghan Foley; Emma Clement; Francesco Muntoni
Journal:  Curr Opin Genet Dev       Date:  2011-03-11       Impact factor: 5.578

5.  Mutations in the human LARGE gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan.

Authors:  Cheryl Longman; Martin Brockington; Silvia Torelli; Cecilia Jimenez-Mallebrera; Colin Kennedy; Nofal Khalil; Lucy Feng; Ravindra K Saran; Thomas Voit; Luciano Merlini; Caroline A Sewry; Susan C Brown; Francesco Muntoni
Journal:  Hum Mol Genet       Date:  2003-09-09       Impact factor: 6.150

6.  Stimulation of synthesis of free chondroitin sulfate chains by beta-D-xylosides in cultured cells.

Authors:  N B Schwartz; L Galligani; P L Ho; A Dorfman
Journal:  Proc Natl Acad Sci U S A       Date:  1974-10       Impact factor: 11.205

7.  LARGE can functionally bypass alpha-dystroglycan glycosylation defects in distinct congenital muscular dystrophies.

Authors:  Rita Barresi; Daniel E Michele; Motoi Kanagawa; Hollie A Harper; Sherri A Dovico; Jakob S Satz; Steven A Moore; Wenli Zhang; Harry Schachter; Jan P Dumanski; Ronald D Cohn; Ichizo Nishino; Kevin P Campbell
Journal:  Nat Med       Date:  2004-06-06       Impact factor: 53.440

8.  O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding.

Authors:  Takako Yoshida-Moriguchi; Liping Yu; Stephanie H Stalnaker; Sarah Davis; Stefan Kunz; Michael Madson; Michael B A Oldstone; Harry Schachter; Lance Wells; Kevin P Campbell
Journal:  Science       Date:  2010-01-01       Impact factor: 47.728

9.  Functional UDP-xylose transport across the endoplasmic reticulum/Golgi membrane in a Chinese hamster ovary cell mutant defective in UDP-xylose Synthase.

Authors:  Hans Bakker; Takuji Oka; Angel Ashikov; Ajit Yadav; Monika Berger; Nadia A Rana; Xiaomei Bai; Yoshifumi Jigami; Robert S Haltiwanger; Jeffrey D Esko; Rita Gerardy-Schahn
Journal:  J Biol Chem       Date:  2008-11-20       Impact factor: 5.157

10.  Crystal structure and cell surface anchorage sites of laminin alpha1LG4-5.

Authors:  David Harrison; Sadaf-Ahmahni Hussain; Ariana C Combs; James M Ervasti; Peter D Yurchenco; Erhard Hohenester
Journal:  J Biol Chem       Date:  2007-02-15       Impact factor: 5.157
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  145 in total

1.  RPTPζ/phosphacan is abnormally glycosylated in a model of muscle-eye-brain disease lacking functional POMGnT1.

Authors:  C A Dwyer; E Baker; H Hu; R T Matthews
Journal:  Neuroscience       Date:  2012-06-19       Impact factor: 3.590

Review 2.  Vertebrate protein glycosylation: diversity, synthesis and function.

Authors:  Kelley W Moremen; Michael Tiemeyer; Alison V Nairn
Journal:  Nat Rev Mol Cell Biol       Date:  2012-06-22       Impact factor: 94.444

3.  Absence of post-phosphoryl modification in dystroglycanopathy mouse models and wild-type tissues expressing non-laminin binding form of α-dystroglycan.

Authors:  Atsushi Kuga; Motoi Kanagawa; Atsushi Sudo; Yiumo Michael Chan; Michiko Tajiri; Hiroshi Manya; Yamato Kikkawa; Motoyoshi Nomizu; Kazuhiro Kobayashi; Tamao Endo; Qi L Lu; Yoshinao Wada; Tatsushi Toda
Journal:  J Biol Chem       Date:  2012-01-23       Impact factor: 5.157

4.  Mislocalization of fukutin protein by disease-causing missense mutations can be rescued with treatments directed at folding amelioration.

Authors:  Masaji Tachikawa; Motoi Kanagawa; Chih-Chieh Yu; Kazuhiro Kobayashi; Tatsushi Toda
Journal:  J Biol Chem       Date:  2012-01-24       Impact factor: 5.157

5.  O-mannosylation of cadherins.

Authors:  Jacques U Baenziger
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-24       Impact factor: 11.205

Review 6.  Understanding human glycosylation disorders: biochemistry leads the charge.

Authors:  Hudson H Freeze
Journal:  J Biol Chem       Date:  2013-01-17       Impact factor: 5.157

7.  Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes.

Authors:  Kunil K Raval; Ran Tao; Brent E White; Willem J De Lange; Chad H Koonce; Junying Yu; Priya S Kishnani; James A Thomson; Deane F Mosher; John C Ralphe; Timothy J Kamp
Journal:  J Biol Chem       Date:  2014-12-08       Impact factor: 5.157

8.  Alterations of dystrophin-associated glycoproteins in the heart lacking dystrophin or dystrophin and utrophin.

Authors:  Katharine M Sharpe; Monica D Premsukh; DeWayne Townsend
Journal:  J Muscle Res Cell Motil       Date:  2013-10-06       Impact factor: 2.698

9.  Biochemical and biophysical changes underlie the mechanisms of basement membrane disruptions in a mouse model of dystroglycanopathy.

Authors:  Peng Zhang; Yuan Yang; Joseph Candiello; Trista L Thorn; Noel Gray; Willi M Halfter; Huaiyu Hu
Journal:  Matrix Biol       Date:  2013-02-27       Impact factor: 11.583

10.  Loss of LARGE2 disrupts functional glycosylation of α-dystroglycan in prostate cancer.

Authors:  Alison K Esser; Michael R Miller; Qin Huang; Melissa M Meier; Daniel Beltran-Valero de Bernabé; Christopher S Stipp; Kevin P Campbell; Charles F Lynch; Brian J Smith; Michael B Cohen; Michael D Henry
Journal:  J Biol Chem       Date:  2012-12-06       Impact factor: 5.157
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