Literature DB >> 22222462

Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression.

Alessandro Serretti1, Alberto Chiesa, Concetta Crisafulli, Isabelle Massat, Sylvie Linotte, Raffaella Calati, Siegfried Kasper, Ursula Bailer, Yves Lecrubier, Martin Fink, Irina Antonijevic, Carlos Forray, Lenore Snyder, Joseph Bollen, Joseph Zohar, Diana De Ronchi, Daniel Souery, Julien Mendlewicz.   

Abstract

In the present study, we aimed to confirm the previous finding of an association between GRIK4 and GNB3 variants (rs195478 and rs5443) and remission and treatment resistance in major depression, using a multicenter sample of 223 patients. We did not find any supporting evidence for such associations. These conflicting data may result from difficulties in the replication of candidate gene association studies.
Copyright © 2012 S. Karger AG, Basel.

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Year:  2012        PMID: 22222462     DOI: 10.1159/000329553

Source DB:  PubMed          Journal:  Neuropsychobiology        ISSN: 0302-282X            Impact factor:   2.328


  8 in total

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Review 6.  Genetic Studies on the Tripartite Glutamate Synapse in the Pathophysiology and Therapeutics of Mood Disorders.

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7.  The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Depression: A Meta-Analysis.

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Review 8.  Genetic variables of the glutamatergic system associated with treatment-resistant depression: A review of the literature.

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Journal:  World J Psychiatry       Date:  2022-07-19
  8 in total

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