AIM: The aim of this study was to investigate the association of microRNA polymorphisms (miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G) in Korean patients with recurrent spontaneous abortion (RSA). METHODS: We conducted a case-control study of 564 Korean women: 330 patients with at least two unexplained consecutive pregnancy losses and 234 healthy controls with at least one live birth and no history of pregnancy loss. RESULTS: RSA patients exhibited significantly different frequencies of the miR-196a2CC (TT+TC vs. CC; adjusted odds ratio [AOR], 1.587; 95% confidence interval [CI], 1.042–2.417) and miR-499AG+GG genotypes (AOR, 1.587; 95% CI, 1.096–2.298) [corrected] compared with the control group. The combination of miR-196a2CC and miR-499AG+GG showed synergistic effects (AOR, 3.541; 95% CI, 1.645–7.624). CONCLUSION: miR-196a2CC, miR-499AG+GG, and the miR-196a2CC/miR-499AG+GG combination are significantly associated with idiopathic RSA in Korean women.
AIM: The aim of this study was to investigate the association of microRNA polymorphisms (miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G) in Korean patients with recurrent spontaneous abortion (RSA). METHODS: We conducted a case-control study of 564 Korean women: 330 patients with at least two unexplained consecutive pregnancy losses and 234 healthy controls with at least one live birth and no history of pregnancy loss. RESULTS:RSApatients exhibited significantly different frequencies of the miR-196a2CC (TT+TC vs. CC; adjusted odds ratio [AOR], 1.587; 95% confidence interval [CI], 1.042–2.417) and miR-499AG+GG genotypes (AOR, 1.587; 95% CI, 1.096–2.298) [corrected] compared with the control group. The combination of miR-196a2CC and miR-499AG+GG showed synergistic effects (AOR, 3.541; 95% CI, 1.645–7.624). CONCLUSION: miR-196a2CC, miR-499AG+GG, and the miR-196a2CC/miR-499AG+GG combination are significantly associated with idiopathic RSA in Korean women.
Authors: Amy E Flowers; Tania L Gonzalez; Nikhil V Joshi; Laura E Eisman; Ekaterina L Clark; Rae A Buttle; Erica Sauro; Rosemarie DiPentino; Yayu Lin; Di Wu; Yizhou Wang; Chintda Santiskulvong; Jie Tang; Bora Lee; Tianyanxin Sun; Jessica L Chan; Erica T Wang; Caroline Jefferies; Kate Lawrenson; Yazhen Zhu; Yalda Afshar; Hsian-Rong Tseng; John Williams; Margareta D Pisarska Journal: Biol Reprod Date: 2022-03-19 Impact factor: 4.161
Authors: Yong Wook Jung; Young Joo Jeon; HyungChul Rah; Ji Hyang Kim; Ji Eun Shin; Dong Hee Choi; Sun Hee Cha; Nam Keun Kim Journal: PLoS One Date: 2014-04-25 Impact factor: 3.240
Authors: Jae Joon Lim; Dong Ah Shin; Young Joo Jeon; Hemant Kumar; Seil Sohn; Hyoung Sik Min; Jang Bo Lee; Sung Uk Kuh; Keung Nyun Kim; Jung Oh Kim; Ok Joon Kim; Alexander E Ropper; Nam Keun Kim; In Bo Han Journal: PLoS One Date: 2016-07-25 Impact factor: 3.240