| Literature DB >> 22222035 |
P J Bindu1, K M Mahadevan, N D Satyanarayan, T R Ravikumar Naik.
Abstract
New 2-chloro-3-formyl quinoline oxime esters were synthesized by the reaction of 2-chloro-3-formyl quinoline oximes with various benzoyl chlorides in the presence of triethyl amine and dichloromethane at 0°C. The DNA photo cleavage studies of some new oxime esters were investigated by neutral agarose gel electrophoresis at different concentrations (40μM and 80μM). Analysis of the cleavage products in agarose gel indicated that few of quinoline oxime esters (3d-i) converted into supercoiled pUC19 plasmid DNA to its nicked or linear form.Entities:
Mesh：
Substances：
Year: 2011 PMID： 22222035 DOI： 10.1016/j.bmcl.2011.12.037
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823