Literature DB >> 2222187

Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein.

H P Weiss1, L Stitz, H Becht.   

Abstract

After covalent attachment of bacterial lipopolysaccharide to the nucleoprotein of influenza A virus, this water-soluble antigen could be incorporated firmly into ISCOM. This potent "immunostimulating complex" induced the production of high antibody titers in mice and could partially protect the animals from a lethal challenge infection. After immunization with ISCOM preparations NP-specific cytotoxic T cell activity could not be demonstrated.

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Year:  1990        PMID： 2222187     DOI： 10.1007/bf01311015

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  28 in total

1.  In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine.

Authors:  K Deres; H Schild; K H Wiesmüller; G Jung; H G Rammensee
Journal:  Nature       Date:  1989-11-30       Impact factor: 49.962

2.  The iscom antigen-presenting system.

Authors:  B Morein
Journal:  Nature       Date:  1988-03-17       Impact factor: 49.962

3.  The mitogenic effects of endotoxin and staphylococcal enterotoxin B on mouse spleen cells and human peripheral lymphocytes.

Authors:  D L Peavy; W H Adler; R T Smith
Journal:  J Immunol       Date:  1970-12       Impact factor: 5.422

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  Early presence of ribonucleoprotein antigen on surface of influenza virus-infected cells.

Authors:  J L Virelizier; A C Allison; J S Oxford; G C Schild
Journal:  Nature       Date:  1977-03-03       Impact factor: 49.962

6.  Iscom of viral envelope proteins protects against Aujeszky's disease.

Authors:  B Morein; S Belák; T Soós; M Rusvai; B S McGwire; K Bognár
Journal:  Vet Microbiol       Date:  1989-06       Impact factor: 3.293

7.  Localisation of the temperature-sensitive defect in the nucleoprotein of an influenza A/FPV/Rostock/34 virus.

Authors:  J Mandler; C Scholtissek
Journal:  Virus Res       Date:  1989-02       Impact factor: 3.303

8.  Cytotoxic T cell lysis of target cells fused with liposomes containing influenza virus haemagglutinin and neuraminidase.

Authors:  L Stitz; R T Huang; H Hengartner; R Rott; R M Zinkernagel
Journal:  J Gen Virol       Date:  1985-06       Impact factor: 3.891

9.  Purified influenza virus nucleoprotein protects mice from lethal infection.

Authors:  D C Wraith; A E Vessey; B A Askonas
Journal:  J Gen Virol       Date:  1987-02       Impact factor: 3.891

10.  Efficacy of influenza haemagglutinin and nucleoprotein as protective antigens against influenza virus infection in mice.

Authors:  M E Andrew; B E Coupar
Journal:  Scand J Immunol       Date:  1988-07       Impact factor: 3.487
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  2 in total

1.  Protection of mice against an influenza virus infection by oral vaccination with viral nucleoprotein incorporated into immunostimulating complexes.

Authors:  K Scheepers; H Becht
Journal:  Med Microbiol Immunol       Date:  1994-11       Impact factor: 3.402

2.  An antigenic epitope of influenza virus nucleoprotein (NP) associated with polymeric forms of NP.

Authors:  Elena N Prokudina; Nataly Semenova; Valery Chumakov; Lothar Stitz
Journal:  Virol J       Date:  2008-02-29       Impact factor: 4.099
  2 in total

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