AIM: To determine whether extremely low-birthweight (ELBW) infants with bilateral compared to unilateral intraventricular haemorrhage (IVH) have worse neurodevelopmental outcomes at 18-22 months. METHODS: A total of 166 ELBW infants (<1000 g) admitted to a Cincinnati NICU from 1998 to 2005 with a head ultrasound showing Grade I-IV IVH and neurodevelopmental assessment at 18-22 months corrected age were included. Multivariable linear and logistic regression models were developed to determine the impact of laterality and grade of IVH and other clinical variables to predict scores on the Bayley Scales of Infant Development, Second Edition, Mental Development Index and Psychomotor Development Index and the combined outcome of neurodevelopmental impairment (NDI). RESULTS: Infants with bilateral grade IV IVH had lower adjusted mean Bayley scores compared with infants with unilateral grade IV IVH. For grades I, II and III IVH, bilaterality of IVH was not associated with lower mean Bayley scores. Infants with grade IV IVH had the highest odds of NDI. The probability of NDI increased with sepsis and postnatal steroid use. CONCLUSION: ELBW infants with bilateral compared to those with unilateral grade IV IVH had worse neurodevelopmental outcomes. Infants with grades I-III IVH had similar outcomes whether they had unilateral or bilateral IVH.
AIM: To determine whether extremely low-birthweight (ELBW) infants with bilateral compared to unilateral intraventricular haemorrhage (IVH) have worse neurodevelopmental outcomes at 18-22 months. METHODS: A total of 166 ELBW infants (<1000 g) admitted to a Cincinnati NICU from 1998 to 2005 with a head ultrasound showing Grade I-IV IVH and neurodevelopmental assessment at 18-22 months corrected age were included. Multivariable linear and logistic regression models were developed to determine the impact of laterality and grade of IVH and other clinical variables to predict scores on the Bayley Scales of Infant Development, Second Edition, Mental Development Index and Psychomotor Development Index and the combined outcome of neurodevelopmental impairment (NDI). RESULTS:Infants with bilateral grade IV IVH had lower adjusted mean Bayley scores compared with infants with unilateral grade IV IVH. For grades I, II and III IVH, bilaterality of IVH was not associated with lower mean Bayley scores. Infants with grade IV IVH had the highest odds of NDI. The probability of NDI increased with sepsis and postnatal steroid use. CONCLUSION: ELBW infants with bilateral compared to those with unilateral grade IV IVH had worse neurodevelopmental outcomes. Infants with grades I-III IVH had similar outcomes whether they had unilateral or bilateral IVH.
Authors: Meike van der Ree; Jozien C Tanis; Koenraad N J A Van Braeckel; Arend F Bos; Elise Roze Journal: Early Hum Dev Date: 2011-07-14 Impact factor: 2.079
Authors: Haim Bassan; Carol B Benson; Catherine Limperopoulos; Henry A Feldman; Steven A Ringer; Elaine Veracruz; Jane E Stewart; Janet S Soul; Donald N Disalvo; Joseph J Volpe; Adré J du Plessis Journal: Pediatrics Date: 2006-06 Impact factor: 7.124
Authors: L S de Vries; A M Roelants-van Rijn; K J Rademaker; I C Van Haastert; F J Beek; F Groenendaal Journal: Eur J Paediatr Neurol Date: 2001 Impact factor: 3.140
Authors: Linda S De Vries; Inge-Lot C Van Haastert; Karin J Rademaker; Corine Koopman; Floris Groenendaal Journal: J Pediatr Date: 2004-06 Impact factor: 4.406
Authors: S Desai; G Athalye-Jape; S Madhala; W Tee; M Sharp; E Nathan; D Shrestha; S Patole Journal: AJNR Am J Neuroradiol Date: 2022-02-24 Impact factor: 3.825
Authors: So Yeon Jung; Young Eun Kim; Won Soon Park; So Yoon Ahn; Dong Kyung Sung; Se In Sung; Kyeung Min Joo; Seong Gi Kim; Yun Sil Chang Journal: Int J Mol Sci Date: 2022-04-18 Impact factor: 6.208
Authors: A S Davis; S R Hintz; R F Goldstein; N Ambalavanan; C M Bann; B J Stoll; E F Bell; S Shankaran; A R Laptook; M C Walsh; E C Hale; N S Newman; A Das; R D Higgins Journal: J Perinatol Date: 2013-12-26 Impact factor: 2.521