Literature DB >> 2221871

Comparison of ofloxacin, gentamicin, and tobramycin concentrations in tears and in vitro MICs for 90% of test organisms.

J Richman1, H Zolezio, D Tang-Liu.   

Abstract

Concentrations of three anti-infective agents in tear film were monitored after one topical application in rabbits. Ofloxacin concentrations exceeded the MIC for 90% of the organisms tested (MIC90) (gram-negative and gram-positive organisms) for 240 min. Tobramycin concentrations exceeded the MIC90 for 10 min. Gentamicin concentrations exceeded the MIC90 for 20 min for gram-positive organisms and 120 min for gram-negative organisms.

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Year:  1990        PMID： 2221871      PMCID： PMC171882          DOI： 10.1128/AAC.34.8.1602

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Comparative in vitro activity of ciprofloxacin, ofloxacin and pefloxacin against resistant clinical isolates.

Authors:  P Periti; T Mazzei; P Nicoletti
Journal:  Chemioterapia       Date:  1987-04

2.  The potential use of quinolones in future ocular antimicrobial therapy.

Authors:  L R Borrmann; I H Leopold
Journal:  Am J Ophthalmol       Date:  1988-08-15       Impact factor: 5.258

3.  Antibacterial activity of ofloxacin and its mode of action.

Authors:  K Sato; Y Inoue; T Fujii; H Aoyama; S Mitsuhashi
Journal:  Infection       Date:  1986       Impact factor: 3.553

4.  The comparative in vitro activity of ofloxacin and selected ophthalmic antimicrobial agents against ocular bacterial isolates.

Authors:  M S Osato; H G Jensen; M D Trousdale; J A Bosso; L R Borrmann; J Frank; P Akers
Journal:  Am J Ophthalmol       Date:  1989-10-15       Impact factor: 5.258

5.  Susceptibility in vitro of gram-positive aerobe and anaerobe bacteria to ofloxacin.

Authors:  E Debbia; S Mannelli; G Gianrossi; G C Schito
Journal:  Drugs Exp Clin Res       Date:  1987

6.  In vitro and in vivo activity of DL-8280, a new oxazine derivative.

Authors:  K Sato; Y Matsuura; M Inoue; T Une; Y Osada; H Ogawa; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1982-10       Impact factor: 5.191

7.  Comparative in vitro antibacterial activity of ofloxacin and ciprofloxacin against some selected gram-positive and gram-negative isolates.

Authors:  P Y Chau; Y K Leung; W W Ng
Journal:  Infection       Date:  1986       Impact factor: 3.553

8.  Development of resistance to nalidixic acid and the fluoroquinolones after the introduction of norfloxacin and ofloxacin.

Authors:  M Kresken; B Wiedemann
Journal:  Antimicrob Agents Chemother       Date:  1988-08       Impact factor: 5.191

9.  The sensitivity of gram-negative and gram-positive bacteria to ofloxacin.

Authors:  A Speciale; S Stefani; F Caccamo; V M Nicolosi; G Nicoletti
Journal:  Drugs Exp Clin Res       Date:  1987

10.  Comparative bioavailability and efficacy of fortified topical tobramycin.

Authors:  M L Gilbert; K R Wilhelmus; M S Osato
Journal:  Invest Ophthalmol Vis Sci       Date:  1987-05       Impact factor: 4.799
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  10 in total

1.  Penetration of topical, oral, and combined administered ofloxacin into the subretinal fluid.

Authors:  O Cekiç; C Batman; U Yasar; Y Totan; N E Basci; A Bozkurt; O Zilelioglu; S O Kayaalp
Journal:  Br J Ophthalmol       Date:  1999-10       Impact factor: 4.638

Review 2.  Treatment of ocular infections with topical antibacterials.

Authors:  J P Leeming
Journal:  Clin Pharmacokinet       Date:  1999-11       Impact factor: 6.447

3.  Increasing bacterial resistance in pediatric acute conjunctivitis (1997-1998).

Authors:  S L Block; J Hedrick; R Tyler; A Smith; R Findlay; E Keegan; D W Stroman
Journal:  Antimicrob Agents Chemother       Date:  2000-06       Impact factor: 5.191

4.  Sodium hyaluronate 0.25% used as a vehicle increases the bioavailability of topically administered gentamicin.

Authors:  S F Bernatchez; C Tabatabay; R Gurny
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1993-03       Impact factor: 3.117

5.  Distribution kinetics of enoxacin and its metabolite oxoenoxacin in excretory fluids of healthy volunteers.

Authors:  U Jaehde; F Sörgel; K G Naber; J Zürcher; W Schunack
Journal:  Antimicrob Agents Chemother       Date:  1995-09       Impact factor: 5.191

6.  Topical ofloxacin compared with gentamicin in the treatment of external ocular infection. Ofloxacin Study Group.

Authors:  A Gwon
Journal:  Br J Ophthalmol       Date:  1992-12       Impact factor: 4.638

7.  Delivery of antibiotics to the eye using a positively charged polysaccharide as vehicle.

Authors:  O Felt; V Baeyens; P Buri; R Gurny
Journal:  AAPS PharmSci       Date:  2001

8.  Polyvinyl Alcohol/Chitosan Single-Layered and Polyvinyl Alcohol/Chitosan/Eudragit RL100 Multi-layered Electrospun Nanofibers as an Ocular Matrix for the Controlled Release of Ofloxacin: an In Vitro and In Vivo Evaluation.

Authors:  Shahla Mirzaeei; Shiva Taghe; Kofi Asare-Addo; Ali Nokhodchi
Journal:  AAPS PharmSciTech       Date:  2021-06-03       Impact factor: 3.246

9.  Improved corneal bioavailability of ofloxacin: biodegradable microsphere-loaded ion-activated in situ gel delivery system.

Authors:  Elshaimaa G Sayed; Amal K Hussein; Khaled A Khaled; Osama A A Ahmed
Journal:  Drug Des Devel Ther       Date:  2015-03-10       Impact factor: 4.162

10.  Pharmacokinetic analysis of topical tobramycin in equine tears by automated immunoassay.

Authors:  Sarah L Czerwinski; Andrew W Lyon; Brian Skorobohach; Renaud Léguillette
Journal:  BMC Vet Res       Date:  2012-08-21       Impact factor: 2.741
  10 in total

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