Literature DB >> 22216501

Alpha-adrenoceptor blocking drugs in asthma.

K R Patel1.   

Abstract

The effect of alpha-adrenoceptor blocking drug, thymoxamine alone and in combination with isoprenaline, was studied on the specific airways conductance (SGaw) in ten patients with extrinsic asthma. Thymoxamine when given together with isoprenaline produced significantly greater increase in SGaw as compared to improvement achieved with isoprenaline alone. It is suggested that the potentiation of isoprenaline induced bronchodilatation by thymoxamine is mediated by increased cyclic AMP formation in the bronchial smooth muscle.

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Year:  1976        PMID： 22216501      PMCID： PMC1428914          DOI： 10.1111/j.1365-2125.1976.tb04882.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  15 in total

1.  In vivo and in vitro studies on alpha-receptors in human airways. Potentiation with bacterial endotoxin.

Authors:  B G Simonsson; N Svedmyr; B E Skoogh; R Andersson; N P Bergh
Journal:  Scand J Respir Dis       Date:  1972

2.  Cyclic adenosine 3',5'-monophosphate in human lung.

Authors:  M A Kaliner; R P Orange; W J Koopman; K F Austen; P J Laraia
Journal:  Biochim Biophys Acta       Date:  1971-10

3.  Competitive blockade of adrenergic alpha-receptors and histamine receptors by thymoxamine.

Authors:  A T Birmingham; J Szolcsányi
Journal:  J Pharm Pharmacol       Date:  1965-07       Impact factor: 3.765

4.  The effect of thymoxamine on histamine induced bronchospasm in man.

Authors:  S Bianco; J P Griffin; P L Kamburoff; F J Prime
Journal:  Br J Dis Chest       Date:  1972-01

5.  Adrenergic receptors in the guinea-pig trachea.

Authors:  B J Everitt; K D Cairncross
Journal:  J Pharm Pharmacol       Date:  1969-02       Impact factor: 3.765

6.  The effect of phentolamine on adenylate cyclase and on isoproterenol stimulation in leukocytes from asthmatic and nonasthmatic subjects.

Authors:  P J Logsdon; D V Carnright; E Middleton; R G Coffey
Journal:  J Allergy Clin Immunol       Date:  1973-09       Impact factor: 10.793

7.  The use and abuse of vasodilator drugs.

Authors:  G Brownlee
Journal:  Angiology       Date:  1966-03       Impact factor: 3.619

Review 8.  Adenyl cyclase as an adrenergic receptor.

Authors:  G A Robison; R W Butcher; E W Sutherland
Journal:  Ann N Y Acad Sci       Date:  1967-02-10       Impact factor: 5.691

9.  Mode of the bronchodilator action of phentolamine.

Authors:  P M Lish; S I Robbins; K W Dungan
Journal:  J Pharmacol Exp Ther       Date:  1968-09       Impact factor: 4.030

10.  Alterations in cyclic adenosine monophosphate metabolism in human bronchial asthma. I. Leukocyte responsiveness to -adrenergic agents.

Authors:  C W Parker; J W Smith
Journal:  J Clin Invest       Date:  1973-01       Impact factor: 14.808
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  2 in total

Review 1.  Combined alpha- and beta-receptor inhibition in the treatment of hypertension.

Authors:  B N Prichard
Journal:  Drugs       Date:  1984       Impact factor: 9.546

Review 2.  The role of adrenoceptors in bronchial asthma.

Authors:  K R Patel
Journal:  J R Coll Physicians Lond       Date:  1979-07
  2 in total

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