Literature DB >> 222157

Cutaneous leishmaniasis--a case with persistent organisms after treatment in presence of normal immune response.

F A Neva, D Wyler, T Nash.   

Abstract

A Peace Corps volunteer in Senegal, West Africa contracted cutaneous leishmaniasis which had several noteworthy features. One of the three presenting cutaneous ulcers was associated with subcutaneous nodules and viable organisms were recovered from healing lesions after multiple courses of treatment, including amphotericin B. Yet, the patient was found to exhibit both humoral and cell mediated features of normal immunologic responsiveness. Ultimately, clinical and parasitological cure occurred. The patient's organism was found to produce lesions in the foot pads of mice.

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Year:  1979        PMID： 222157

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  23 in total

1.  Interleukin-12 is capable of generating an antigen-specific Th1-type response in the presence of an ongoing infection-driven Th2-type response.

Authors:  L R Schopf; J L Bliss; L M Lavigne; C L Chung; S F Wolf; J P Sypek
Journal:  Infect Immun       Date:  1999-05       Impact factor: 3.441

2.  Serological activity against galactosyl-alpha(1-3)galactose in sera from patients with several kinetoplastida infections.

Authors:  J L Avila; M Rojas; H Towbin
Journal:  J Clin Microbiol       Date:  1988-01       Impact factor: 5.948

3.  Persistence of elevated levels of galactosyl-alpha(1-3)galactose antibodies in sera from patients cured of visceral leishmaniasis.

Authors:  J L Avila; M Rojas; L García
Journal:  J Clin Microbiol       Date:  1988-09       Impact factor: 5.948

4.  In vitro parasite-monocyte interactions in human leishmaniasis. Evidence for an active role of the parasite in attachment.

Authors:  D J Wyler
Journal:  J Clin Invest       Date:  1982-07       Impact factor: 14.808

5.  In vitro parasite-monocyte interactions in human leishmaniasis: effect of enzyme treatments on attachment.

Authors:  D J Wyler; K Suzuki
Journal:  Infect Immun       Date:  1983-10       Impact factor: 3.441

6.  Treatment of experimental cutaneous leishmaniasis with liposome-intercalated amphotericin B.

Authors:  C B Panosian; M Barza; F Szoka; D J Wyler
Journal:  Antimicrob Agents Chemother       Date:  1984-05       Impact factor: 5.191

7.  In vitro parasite-monocyte interactions in human leishmaniasis: possible role of fibronectin in parasite attachment.

Authors:  D J Wyler; J P Sypek; J A McDonald
Journal:  Infect Immun       Date:  1985-08       Impact factor: 3.441

8.  Identification of cross-reactive promastigote cell surface antigens of some leishmanial stocks by 125I labeling and immunoprecipitation.

Authors:  P R Gardiner; C L Jaffe; D M Dwyer
Journal:  Infect Immun       Date:  1984-02       Impact factor: 3.441

9.  T-cell hybridomas reveal two distinct mechanisms of antileishmanial defense.

Authors:  J P Sypek; D J Wyler
Journal:  Infect Immun       Date:  1990-05       Impact factor: 3.441

10.  Leishmania priming of human dendritic cells for CD40 ligand-induced interleukin-12p70 secretion is strain and species dependent.

Authors:  Mary Ann McDowell; Mary Marovich; Rosalia Lira; Michael Braun; David Sacks
Journal:  Infect Immun       Date:  2002-08       Impact factor: 3.441
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