Literature DB >> 22215472

EMT in carcinoma progression and dissemination: facts, unanswered questions, and clinical considerations.

Jeremy Bastid1.   

Abstract

Over the past decade, much effort has been made to understand how cancers metastasize. In deciphering the metastatic process, a vast amount of work has focused on the role of the epithelial to mesenchymal transition (EMT), which, in experimental models, confers tumor cells with invasive and metastatic abilities, resistance to therapies, as well as cancer stem cell phenotype-properties that have a major impact on cancer prognosis. Searching "EMT and cancer" in PubMed retrieves thousands of original research articles, yet, we haven't answered the most basic question in the field: has EMT any relevance in human tumors?

Entities:  

Mesh：

Year:  2012        PMID： 22215472     DOI： 10.1007/s10555-011-9344-6

Source DB:  PubMed          Journal:  Cancer Metastasis Rev        ISSN： 0167-7659            Impact factor:   9.264


  41 in total

1.  Tumor microenvironmental signaling elicits epithelial-mesenchymal plasticity through cooperation with transforming genetic events.

Authors:  Damian J Junk; Rocky Cipriano; Benjamin L Bryson; Hannah L Gilmore; Mark W Jackson
Journal:  Neoplasia       Date:  2013-09       Impact factor: 5.715

2.  Influence of preoperative transcatheter arterial chemoembolization on gene expression in the HIF-1α pathway in patients with hepatocellular carcinoma.

Authors:  Weiguang Xu; Jung-Hee Kwon; Young Ho Moon; Young Bae Kim; Yun Suk Yu; Namgyu Lee; Kwan Yong Choi; Yun Soo Kim; Yong Keun Park; Bong Wan Kim; Hee Jung Wang
Journal:  J Cancer Res Clin Oncol       Date:  2014-05-23       Impact factor: 4.553

3.  TES was epigenetically silenced and suppressed the epithelial-mesenchymal transition in breast cancer.

Authors:  Yang Yongbin; Li Jinghua; Zhao Zhanxue; Zang Aimin; Jia Youchao; Shang Yanhong; Jiao Manjing
Journal:  Tumour Biol       Date:  2014-08-15

4.  The prognostic significance of bromodomain PHD-finger transcription factor in colorectal carcinoma and association with vimentin and E-cadherin.

Authors:  Shuai Xiao; Longfei Liu; Xianzhou Lu; Jianwu Long; Xiaojun Zhou; Min Fang
Journal:  J Cancer Res Clin Oncol       Date:  2015-02-26       Impact factor: 4.553

Review 5.  Microenvironmental regulation of epithelial-mesenchymal transitions in cancer.

Authors:  Dingcheng Gao; Linda T Vahdat; Stephen Wong; Jenny C Chang; Vivek Mittal
Journal:  Cancer Res       Date:  2012-09-20       Impact factor: 12.701

6.  Vimentin immunoexpression is associated with higher tumor grade, metastasis, and shorter survival in colorectal cancer.

Authors:  Jaudah Al-Maghrabi
Journal:  Int J Clin Exp Pathol       Date:  2020-03-01

7.  Mib1 contributes to persistent directional cell migration by regulating the Ctnnd1-Rac1 pathway.

Authors:  Takamasa Mizoguchi; Shoko Ikeda; Saori Watanabe; Michiko Sugawara; Motoyuki Itoh
Journal:  Proc Natl Acad Sci U S A       Date:  2017-10-16       Impact factor: 11.205

8.  Clinical Evolution of Epithelial-Mesenchymal Transition in Human Carcinomas.

Authors:  Tony Navas; Robert J Kinders; Scott M Lawrence; Katherine V Ferry-Galow; Suzanne Borgel; Melinda G Hollingshead; Apurva K Srivastava; Sergio Y Alcoser; Hala R Makhlouf; Rodrigo Chuaqui; Deborah F Wilsker; Mariam M Konaté; Sarah B Miller; Andrea Regier Voth; Li Chen; Tomas Vilimas; Jyothi Subramanian; Lawrence Rubinstein; Shivaani Kummar; Alice P Chen; Donald P Bottaro; James H Doroshow; Ralph E Parchment
Journal:  Cancer Res       Date:  2019-11-15       Impact factor: 12.701

9.  Biological and clinical implications of cancer stem cells in primary brain tumors.

Authors:  Marcello Maugeri-Saccà; Simona Di Martino; Ruggero De Maria
Journal:  Front Oncol       Date:  2013-01-25       Impact factor: 6.244

10.  Mesenchymal stromal cells induce epithelial-to-mesenchymal transition in human colorectal cancer cells through the expression of surface-bound TGF-β.

Authors:  Valentina Mele; Manuele G Muraro; Diego Calabrese; Dennis Pfaff; Nunzia Amatruda; Francesca Amicarella; Brynn Kvinlaug; Chiara Bocelli-Tyndall; Ivan Martin; Therese J Resink; Michael Heberer; Daniel Oertli; Luigi Terracciano; Giulio C Spagnoli; Giandomenica Iezzi
Journal:  Int J Cancer       Date:  2014-01-30       Impact factor: 7.396
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