Literature DB >> 22213347

Innovative collagen nano-hydroxyapatite scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone formation.

Caroline M Curtin1, Gráinne M Cunniffe, Frank G Lyons, Kazuhisa Bessho, Glenn R Dickson, Garry P Duffy, Fergal J O'Brien.   

Abstract

The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells (MSCs) resulting in high calcium production.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22213347     DOI： 10.1002/adma.201103828

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  36 in total

Review 1.  Designing protein-based biomaterials for medical applications.

Authors:  Jennifer E Gagner; Wookhyun Kim; Elliot L Chaikof
Journal:  Acta Biomater       Date:  2013-10-09       Impact factor: 8.947

2.  Mineralized collagen scaffolds induce hMSC osteogenesis and matrix remodeling.

Authors:  Daniel W Weisgerber; Steven R Caliari; Brendan A C Harley
Journal:  Biomater Sci       Date:  2015-03       Impact factor: 6.843

3.  Collagen-GAG scaffold biophysical properties bias MSC lineage choice in the presence of mixed soluble signals.

Authors:  Steven R Caliari; Brendan A C Harley
Journal:  Tissue Eng Part A       Date:  2014-03-25       Impact factor: 3.845

Review 4.  Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances.

Authors:  Mahdi Karimi; Parham Sahandi Zangabad; Alireza Ghasemi; Mohammad Amiri; Mohsen Bahrami; Hedieh Malekzad; Hadi Ghahramanzadeh Asl; Zahra Mahdieh; Mahnaz Bozorgomid; Amir Ghasemi; Mohammad Reza Rahmani Taji Boyuk; Michael R Hamblin
Journal:  ACS Appl Mater Interfaces       Date:  2016-08-11       Impact factor: 9.229

Review 5.  Integration of drug, protein, and gene delivery systems with regenerative medicine.

Authors:  Elizabeth R Lorden; Howard M Levinson; Kam W Leong
Journal:  Drug Deliv Transl Res       Date:  2015-04       Impact factor: 4.617

6.  Effect of different hydroxyapatite incorporation methods on the structural and biological properties of porous collagen scaffolds for bone repair.

Authors:  Alan J Ryan; John P Gleeson; Amos Matsiko; Emmet M Thompson; Fergal J O'Brien
Journal:  J Anat       Date:  2014-11-20       Impact factor: 2.610

7.  An efficient, non-viral dendritic vector for gene delivery in tissue engineering.

Authors:  D P Walsh; A Heise; F J O'Brien; S-A Cryan
Journal:  Gene Ther       Date:  2017-09-14       Impact factor: 5.250

8.  Non-viral gene-activated matrices: next generation constructs for bone repair.

Authors:  Erica G Tierney; Garry P Duffy; Sally-Ann Cryan; Caroline M Curtin; Fergal J O'Brien
Journal:  Organogenesis       Date:  2013-01-01       Impact factor: 2.500

9.  Structural and biochemical modification of a collagen scaffold to selectively enhance MSC tenogenic, chondrogenic, and osteogenic differentiation.

Authors:  Steven R Caliari; Brendan A C Harley
Journal:  Adv Healthc Mater       Date:  2014-02-25       Impact factor: 9.933

Review 10.  Matrix-based gene delivery for tissue repair.

Authors:  Cynthia Cam; Tatiana Segura
Journal:  Curr Opin Biotechnol       Date:  2013-05-14       Impact factor: 9.740
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