Literature DB >> 22213121

Medical therapies with adult stem/progenitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations.

Darwin J Prockop1, Joo Youn Oh.   

Abstract

There is currently great interest in the use of mesenchymal stem/stromal cells (MSCs) for the therapy of many diseases of animals and humans. However, we are still left with the serious challenges in explaining the beneficial effects of the cells. Hence, it is essential to work backward from dramatic results obtained in vivo to the cellular and molecular explanations in order to discover the secrets of MSCs. This review will focus on recent data that have changed the paradigms for understanding the therapeutic potentials of MSCs.
Copyright © 2011 Wiley Periodicals, Inc.

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Year:  2012        PMID： 22213121      PMCID： PMC4147853          DOI： 10.1002/jcb.24046

Source DB:  PubMed          Journal:  J Cell Biochem        ISSN： 0730-2312            Impact factor:   4.429


  64 in total

1.  Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-α stimulated gene/protein 6.

Authors:  Gavin W Roddy; Joo Youn Oh; Ryang Hwa Lee; Thomas J Bartosh; Joni Ylostalo; Katie Coble; Robert H Rosa; Darwin J Prockop
Journal:  Stem Cells       Date:  2011-10       Impact factor: 6.277

Review 2.  IL-1 pathways in inflammation and human diseases.

Authors:  Cem Gabay; Céline Lamacchia; Gaby Palmer
Journal:  Nat Rev Rheumatol       Date:  2010-02-23       Impact factor: 20.543

Review 3.  Adult bone marrow stem/progenitor cells (MSCs) are preconditioned by microenvironmental "niches" in culture: a two-stage hypothesis for regulation of MSC fate.

Authors:  Carl A Gregory; Joni Ylostalo; Darwin J Prockop
Journal:  Sci STKE       Date:  2005-07-26

4.  Mitochondrial transfer between cells can rescue aerobic respiration.

Authors:  Jeffrey L Spees; Scott D Olson; Mandolin J Whitney; Darwin J Prockop
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-23       Impact factor: 11.205

5.  Differentiation of single cell derived human mesenchymal stem cells into cells with a neuronal phenotype: RNA and microRNA expression profile.

Authors:  Francesca Crobu; Veronica Latini; Maria Franca Marongiu; Valeria Sogos; Franca Scintu; Susanna Porcu; Carla Casu; Manuela Badiali; Adele Sanna; Maria Francesca Manchinu; Maria Serafina Ristaldi
Journal:  Mol Biol Rep       Date:  2011-07-20       Impact factor: 2.316

Review 6.  Stromal stem cells: marrow-derived osteogenic precursors.

Authors:  M Owen; A J Friedenstein
Journal:  Ciba Found Symp       Date:  1988

7.  Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing.

Authors:  Qun-Zhou Zhang; Wen-Ru Su; Shi-Hong Shi; Petra Wilder-Smith; Andy Peng Xiang; Alex Wong; Andrew L Nguyen; Chan Wook Kwon; Anh D Le
Journal:  Stem Cells       Date:  2010-10       Impact factor: 6.277

8.  Comparison of mesenchymal tissues-derived stem cells for in vivo chondrogenesis: suitable conditions for cell therapy of cartilage defects in rabbit.

Authors:  Hideyuki Koga; Takeshi Muneta; Tsuyoshi Nagase; Akimoto Nimura; Young-Jin Ju; Tomoyuki Mochizuki; Ichiro Sekiya
Journal:  Cell Tissue Res       Date:  2008-06-17       Impact factor: 5.249

9.  Mesenchymal stem cells.

Authors:  A I Caplan
Journal:  J Orthop Res       Date:  1991-09       Impact factor: 3.494

10.  Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects.

Authors:  Luis A Ortiz; Frederica Gambelli; Christine McBride; Dina Gaupp; Melody Baddoo; Naftali Kaminski; Donald G Phinney
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-18       Impact factor: 12.779
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  49 in total

Review 1.  Mesenchymal stem cell-based gene therapy for erectile dysfunction.

Authors:  J H Kim; H J Lee; Y S Song
Journal:  Int J Impot Res       Date:  2016-02-18       Impact factor: 2.896

2.  Mitochondria to the rescue.

Authors:  Darwin J Prockop
Journal:  Nat Med       Date:  2012-05-04       Impact factor: 53.440

3.  Local transplantation is an effective method for cell delivery in the osteogenesis imperfecta murine model.

Authors:  Penelope Pauley; Brya G Matthews; Liping Wang; Nathaniel A Dyment; Igor Matic; David W Rowe; Ivo Kalajzic
Journal:  Int Orthop       Date:  2014-01-03       Impact factor: 3.075

4.  Further proof for an unpopular concept: a single cell from bone marrow can serve as a stem cell for both hematopoiesis and osteogenesis.

Authors:  Darwin J Prockop
Journal:  Mol Ther       Date:  2013-06       Impact factor: 11.454

Review 5.  Stem cells, cell therapies, and bioengineering in lung biology and diseases. Comprehensive review of the recent literature 2010-2012.

Authors:  Daniel J Weiss
Journal:  Ann Am Thorac Soc       Date:  2013-10

6.  Stem cells and cell therapies in lung biology and diseases: conference report.

Authors:  Daniel J Weiss; Jason H T Bates; Thomas Gilbert; W Conrad Liles; Carolyn Lutzko; Jay Rajagopal; Darwin Prockop
Journal:  Ann Am Thorac Soc       Date:  2013-10

7.  Mesenchymal stromal cell characteristics vary depending on their origin.

Authors:  Heike Wegmeyer; Ann-Marie Bröske; Mathias Leddin; Karin Kuentzer; Anna Katharina Nisslbeck; Julia Hupfeld; Kornelius Wiechmann; Jennifer Kuhlen; Christoffer von Schwerin; Carsten Stein; Saskia Knothe; Jürgen Funk; Ralf Huss; Markus Neubauer
Journal:  Stem Cells Dev       Date:  2013-06-22       Impact factor: 3.272

8.  Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells.

Authors:  Ling Ling; Emily T Camilleri; Torben Helledie; Rebekah M Samsonraj; Drew M Titmarsh; Ren Jie Chua; Oliver Dreesen; Christian Dombrowski; David A Rider; Mario Galindo; Ian Lee; Wanjin Hong; James H Hui; Victor Nurcombe; Andre J van Wijnen; Simon M Cool
Journal:  Gene       Date:  2015-10-17       Impact factor: 3.688

9.  Amide-type local anesthetics and human mesenchymal stem cells: clinical implications for stem cell therapy.

Authors:  Ryan C Dregalla; Nicolette F Lyons; Patrick D Reischling; Christopher J Centeno
Journal:  Stem Cells Transl Med       Date:  2014-01-16       Impact factor: 6.940

10.  Stem cells and myocardial regeneration: cooperation wins over competition.

Authors:  Annarosa Leri; Piero Anversa
Journal:  Circulation       Date:  2012-12-05       Impact factor: 29.690
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