Literature DB >> 22211977

Is it time for in silico simulation of drug cardiac side effects?

Gary R Mirams1, Denis Noble.   

Abstract

Cardiac simulation is used to integrate information on drug action to predict side effects on the whole heart. Could simulation begin to replace animal models?
© 2011 New York Academy of Sciences.

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Substances：

Year:  2011        PMID： 22211977     DOI： 10.1111/j.1749-6632.2011.06324.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  8 in total

1.  Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment.

Authors:  Ryan C Elkins; Mark R Davies; Stephen J Brough; David J Gavaghan; Yi Cui; Najah Abi-Gerges; Gary R Mirams
Journal:  J Pharmacol Toxicol Methods       Date:  2013-05-05       Impact factor: 1.950

2.  Predicting the bounds of large chaotic systems using low-dimensional manifolds.

Authors:  Asger M Haugaard
Journal:  PLoS One       Date:  2017-06-23       Impact factor: 3.240

3.  Systems Toxicology: Real World Applications and Opportunities.

Authors:  Thomas Hartung; Rex E FitzGerald; Paul Jennings; Gary R Mirams; Manuel C Peitsch; Amin Rostami-Hodjegan; Imran Shah; Martin F Wilks; Shana J Sturla
Journal:  Chem Res Toxicol       Date:  2017-03-31       Impact factor: 3.739

Review 4.  Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.

Authors:  Gary R Mirams; Mark R Davies; Yi Cui; Peter Kohl; Denis Noble
Journal:  Br J Pharmacol       Date:  2012-11       Impact factor: 8.739

5.  Chaste: an open source C++ library for computational physiology and biology.

Authors:  Gary R Mirams; Christopher J Arthurs; Miguel O Bernabeu; Rafel Bordas; Jonathan Cooper; Alberto Corrias; Yohan Davit; Sara-Jane Dunn; Alexander G Fletcher; Daniel G Harvey; Megan E Marsh; James M Osborne; Pras Pathmanathan; Joe Pitt-Francis; James Southern; Nejib Zemzemi; David J Gavaghan
Journal:  PLoS Comput Biol       Date:  2013-03-14       Impact factor: 4.475

Review 6.  Combining wet and dry research: experience with model development for cardiac mechano-electric structure-function studies.

Authors:  T Alexander Quinn; Peter Kohl
Journal:  Cardiovasc Res       Date:  2013-01-17       Impact factor: 10.787

7.  Prediction of Thorough QT study results using action potential simulations based on ion channel screens.

Authors:  Gary R Mirams; Mark R Davies; Stephen J Brough; Matthew H Bridgland-Taylor; Yi Cui; David J Gavaghan; Najah Abi-Gerges
Journal:  J Pharmacol Toxicol Methods       Date:  2014-07-31       Impact factor: 1.950

Review 8.  Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment.

Authors:  T A Collins; L Bergenholm; T Abdulla; Jwt Yates; N Evans; M J Chappell; J T Mettetal
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2015-03-11
  8 in total

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