Literature DB >> 2221158

Influence of patient-related variables on clozapine plasma levels.

C Haring1, W W Fleischhacker, P Schett, C Humpel, C Barnas, A Saria.   

Abstract

The authors investigated the clozapine plasma levels of 148 psychiatric inpatients. Multiple regression analysis revealed a linear relationship between dose of clozapine and plasma concentrations. The analysis showed a significant influence of dose, sex, smoking, weight, and age on the plasma concentrations of clozapine under clinical conditions. These results remained significant when clozapine doses below 150 mg/day and above 500 mg/day were excluded from the analysis.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2221158     DOI： 10.1176/ajp.147.11.1471

Source DB:  PubMed          Journal:  Am J Psychiatry        ISSN： 0002-953X            Impact factor:   18.112


  21 in total

1.  Sex and age differences in the pharmacokinetics of alosetron.

Authors:  K M Koch; J L Palmer; N Noordin; J J Tomlinson; C Baidoo
Journal:  Br J Clin Pharmacol       Date:  2002-03       Impact factor: 4.335

Review 2.  Clinical profile of clozapine: adverse reactions and agranulocytosis.

Authors:  J A Lieberman; A Z Safferman
Journal:  Psychiatr Q       Date:  1992

Review 3.  New atypical antipsychotics. Experience and utility in the elderly.

Authors:  R A Sweet; B G Pollock
Journal:  Drugs Aging       Date:  1998-02       Impact factor: 3.923

4.  Clozapine: an appraisal of its pharmacoeconomic benefits in the treatment of schizophrenia.

Authors:  A Fitton; P Benfield
Journal:  Pharmacoeconomics       Date:  1993-08       Impact factor: 4.981

Review 5.  Drug treatment of schizophrenia in the 1990s. Achievements and future possibilities in optimising outcomes.

Authors:  W W Fleischhacker; M Hummer
Journal:  Drugs       Date:  1997-06       Impact factor: 9.546

6.  EEG alterations in patients treated with clozapine in relation to plasma levels.

Authors:  C Haring; C Neudorfer; J Schwitzer; M Hummer; A Saria; H Hinterhuber; W W Fleischhacker
Journal:  Psychopharmacology (Berl)       Date:  1994-02       Impact factor: 4.530

7.  Extrapyramidal side effects of clozapine and haloperidol.

Authors:  M Kurz; M Hummer; H Oberbauer; W W Fleischhacker
Journal:  Psychopharmacology (Berl)       Date:  1995-03       Impact factor: 4.530

Review 8.  Clozapine plasma level monitoring: current status.

Authors:  T B Cooper
Journal:  Psychiatr Q       Date:  1996

9.  Effect of treatment duration on plasma levels of clozapine and N-desmethylclozapine in men and women.

Authors:  M Fabrazzo; G Esposito; R Fusco; M Maj
Journal:  Psychopharmacology (Berl)       Date:  1996-03       Impact factor: 4.530

Review 10.  Clozapine. A review of its pharmacological properties, and therapeutic use in schizophrenia.

Authors:  A Fitton; R C Heel
Journal:  Drugs       Date:  1990-11       Impact factor: 9.546
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.