Literature DB >> 22211192

CRKL as a lung cancer oncogene and mediator of acquired resistance to EGFR inhibitors: is it all that it is cracked up to be?

Marc Ladanyi1.   

Abstract

Cheung and colleagues demonstrate that amplified CRKL can function as a driver oncogene in lung adenocarcinoma, activating both RAS and RAP1 to induce mitogen-activated protein kinase signaling. In addition, they show that CRKL amplification may be another mechanism for primary or acquired resistance to epidermal growth factor receptor kinase inhibitors. 2011 AACR

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 22211192      PMCID： PMC3247017          DOI： 10.1158/2159-8290.CD-11-0295

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   39.397


  21 in total

1.  Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis.

Authors:  Xiaojun Zhao; Barbara A Weir; Thomas LaFramboise; Ming Lin; Rameen Beroukhim; Levi Garraway; Javad Beheshti; Jeffrey C Lee; Katsuhiko Naoki; William G Richards; David Sugarbaker; Fei Chen; Mark A Rubin; Pasi A Jänne; Luc Girard; John Minna; David Christiani; Cheng Li; William R Sellers; Matthew Meyerson
Journal:  Cancer Res       Date:  2005-07-01       Impact factor: 12.701

Review 2.  Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2.

Authors:  Robert K Dearth; Xiaojiang Cui; Hyun-Jung Kim; Darryl L Hadsell; Adrian V Lee
Journal:  Cell Cycle       Date:  2007-03-20       Impact factor: 4.534

Review 3.  Crk family adaptors-signalling complex formation and biological roles.

Authors:  S M Feller
Journal:  Oncogene       Date:  2001-10-01       Impact factor: 9.867

4.  Characterizing the cancer genome in lung adenocarcinoma.

Authors:  Barbara A Weir; Michele S Woo; Gad Getz; Sven Perner; Li Ding; Rameen Beroukhim; William M Lin; Michael A Province; Aldi Kraja; Laura A Johnson; Kinjal Shah; Mitsuo Sato; Roman K Thomas; Justine A Barletta; Ingrid B Borecki; Stephen Broderick; Andrew C Chang; Derek Y Chiang; Lucian R Chirieac; Jeonghee Cho; Yoshitaka Fujii; Adi F Gazdar; Thomas Giordano; Heidi Greulich; Megan Hanna; Bruce E Johnson; Mark G Kris; Alex Lash; Ling Lin; Neal Lindeman; Elaine R Mardis; John D McPherson; John D Minna; Margaret B Morgan; Mark Nadel; Mark B Orringer; John R Osborne; Brad Ozenberger; Alex H Ramos; James Robinson; Jack A Roth; Valerie Rusch; Hidefumi Sasaki; Frances Shepherd; Carrie Sougnez; Margaret R Spitz; Ming-Sound Tsao; David Twomey; Roel G W Verhaak; George M Weinstock; David A Wheeler; Wendy Winckler; Akihiko Yoshizawa; Soyoung Yu; Maureen F Zakowski; Qunyuan Zhang; David G Beer; Ignacio I Wistuba; Mark A Watson; Levi A Garraway; Marc Ladanyi; William D Travis; William Pao; Mark A Rubin; Stacey B Gabriel; Richard A Gibbs; Harold E Varmus; Richard K Wilson; Eric S Lander; Matthew Meyerson
Journal:  Nature       Date:  2007-11-04       Impact factor: 49.962

5.  MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.

Authors:  Jeffrey A Engelman; Kreshnik Zejnullahu; Tetsuya Mitsudomi; Youngchul Song; Courtney Hyland; Joon Oh Park; Neal Lindeman; Christopher-Michael Gale; Xiaojun Zhao; James Christensen; Takayuki Kosaka; Alison J Holmes; Andrew M Rogers; Federico Cappuzzo; Tony Mok; Charles Lee; Bruce E Johnson; Lewis C Cantley; Pasi A Jänne
Journal:  Science       Date:  2007-04-26       Impact factor: 47.728

6.  A gene-alteration profile of human lung cancer cell lines.

Authors:  Raquel Blanco; Reika Iwakawa; Moying Tang; Takashi Kohno; Barbara Angulo; Ruben Pio; Luis M Montuenga; John D Minna; Jun Yokota; Montse Sanchez-Cespedes
Journal:  Hum Mutat       Date:  2009-08       Impact factor: 4.878

7.  Genetic predictors of MEK dependence in non-small cell lung cancer.

Authors:  Christine A Pratilas; Aphrothiti J Hanrahan; Ensar Halilovic; Yogindra Persaud; Junichi Soh; Dhananjay Chitale; Hisayuki Shigematsu; Hiromasa Yamamoto; Ayana Sawai; Manickam Janakiraman; Barry S Taylor; William Pao; Shinichi Toyooka; Marc Ladanyi; Adi Gazdar; Neal Rosen; David B Solit
Journal:  Cancer Res       Date:  2008-11-15       Impact factor: 12.701

8.  Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line.

Authors:  Atsuko Ogino; Hiroyuki Kitao; Seiki Hirano; Akiko Uchida; Masamichi Ishiai; Toshiyuki Kozuki; Nagio Takigawa; Minoru Takata; Katsuyuki Kiura; Mitsune Tanimoto
Journal:  Cancer Res       Date:  2007-08-15       Impact factor: 12.701

9.  An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors.

Authors:  D Chitale; Y Gong; B S Taylor; S Broderick; C Brennan; R Somwar; B Golas; L Wang; N Motoi; J Szoke; J M Reinersman; J Major; C Sander; V E Seshan; M F Zakowski; V Rusch; W Pao; W Gerald; M Ladanyi
Journal:  Oncogene       Date:  2009-06-15       Impact factor: 9.867

10.  Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers.

Authors:  Hihu Wing Cheung; Jinyan Du; Jesse S Boehm; Frank He; Barbara A Weir; Xiaoxing Wang; Mohit Butaney; Lecia V Sequist; Biao Luo; Jeffrey A Engelman; David E Root; Matthew Meyerson; Todd R Golub; Pasi A Jänne; William C Hahn
Journal:  Cancer Discov       Date:  2011-10-17       Impact factor: 39.397
View more
  4 in total

1.  Overexpression of CRKL correlates with malignant cell proliferation in breast cancer.

Authors:  Tingting Zhao; Zhifeng Miao; Zhenning Wang; Yingying Xu; Jianhua Wu; Xingyu Liu; Yi You; Jiguang Li
Journal:  Tumour Biol       Date:  2013-05-19

2.  Clinical significance and biological roles of CRKL in human bladder carcinoma.

Authors:  Bin Han; Lan Luan; Zhenqun Xu; Bin Wu
Journal:  Tumour Biol       Date:  2013-12-28

3.  Crk-like adapter protein is overexpressed in cervical carcinoma, facilitates proliferation, invasion and chemoresistance, and regulates Src and Akt signaling.

Authors:  Hong Ji; Bo Li; Shitai Zhang; Zheng He; Yang Zhou; Ling Ouyang
Journal:  Oncol Lett       Date:  2016-09-21       Impact factor: 2.967

4.  MicroRNA-320 inhibits invasion and induces apoptosis by targeting CRKL and inhibiting ERK and AKT signaling in gastric cancer cells.

Authors:  Yue Zhao; Qianze Dong; Enhua Wang
Journal:  Onco Targets Ther       Date:  2017-02-20       Impact factor: 4.147
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.