| Literature DB >> 22210435 |
Richard Schwameis1, Manfred Fille, Mohammad Manafi, Markus Zeitlinger, Robert Sauermann.
Abstract
Linezolid is considered for treatment of central nervous system (CNS) infections caused by multidrug-resistant Gram-positive bacteria. Therefore, the influence of cerebrospinal fluid (CSF) on the antimicrobial activity of linezolid was evaluated in vitro. Time-kill curves were conducted in CSF and Mueller-Hinton broth (MHB) using Staphylococcus aureus (ATCC 29213) and Staphylococcus epidermidis (ATCC 12228) strains. In CSF lower linezolid concentrations were needed against S. aureus (1× MIC) and S. epidermidis (0.5× MIC) to achieve bacteriostasis than in MHB (4× MIC for both strains). Good activity of linezolid in CSF supports performance of clinical trials evaluating its potential for treatment of CNS infections.Entities:
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Year: 2011 PMID： 22210435 DOI： 10.1016/j.resmic.2011.12.004
Source DB: PubMed Journal: Res Microbiol ISSN： 0923-2508 Impact factor: 3.992