OBJECTIVE: To assess the association of baseline anxiety with depression persistence and change in depressive symptoms 6 months after cardiac hospitalization. METHODS: Data were analyzed from 137 depressed patients hospitalized on inpatient cardiac units for acute coronary syndrome, decompensated heart failure, or arrhythmia and who were enrolled in a randomized trial of collaborative care depression management. Subjects' demographic, medical, and psychiatric information at baseline was compiled. Measures of health-related quality of life, cardiac symptoms, and psychiatric symptoms, including the Hospital Anxiety and Depression Scale-anxiety subscale (HADS-A) for anxiety, were obtained at baseline and serially during a 6-month follow-up period. The association between baseline HADS-A score and depression persistence (<50% reduction in depressive symptoms on the Patient Health Questionnaire-9) at 6 months was assessed by multivariate logistic regression accounting for the effects of multiple relevant medical and psychological covariates. The association between baseline HADS-A score and improvement in depressive symptoms (Patient Health Questionnaire-9) from baseline at 6 months was assessed by linear regression accounting for the same covariates. RESULTS:Baseline HADS-A score was independently associated with depression persistence at 6 months (odds ratio = 1.11, 95% confidence interval = 1.01-1.22, p = .03). Likewise, higher baseline HADS-A score was associated with less improvement in depressive symptoms at 6 months (β = -0.34, p = .01). CONCLUSIONS: Among a cohort of depressed cardiac patients, higher baseline anxiety score was linked with lesser improvement in depressive symptoms and increased likelihood of depression persistence at 6 months, independent of multiple relevant covariates. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00847132.
RCT Entities:
OBJECTIVE: To assess the association of baseline anxiety with depression persistence and change in depressive symptoms 6 months after cardiac hospitalization. METHODS: Data were analyzed from 137 depressedpatients hospitalized on inpatient cardiac units for acute coronary syndrome, decompensated heart failure, or arrhythmia and who were enrolled in a randomized trial of collaborative care depression management. Subjects' demographic, medical, and psychiatric information at baseline was compiled. Measures of health-related quality of life, cardiac symptoms, and psychiatric symptoms, including the Hospital Anxiety and Depression Scale-anxiety subscale (HADS-A) for anxiety, were obtained at baseline and serially during a 6-month follow-up period. The association between baseline HADS-A score and depression persistence (<50% reduction in depressive symptoms on the Patient Health Questionnaire-9) at 6 months was assessed by multivariate logistic regression accounting for the effects of multiple relevant medical and psychological covariates. The association between baseline HADS-A score and improvement in depressive symptoms (Patient Health Questionnaire-9) from baseline at 6 months was assessed by linear regression accounting for the same covariates. RESULTS: Baseline HADS-A score was independently associated with depression persistence at 6 months (odds ratio = 1.11, 95% confidence interval = 1.01-1.22, p = .03). Likewise, higher baseline HADS-A score was associated with less improvement in depressive symptoms at 6 months (β = -0.34, p = .01). CONCLUSIONS: Among a cohort of depressed cardiac patients, higher baseline anxiety score was linked with lesser improvement in depressive symptoms and increased likelihood of depression persistence at 6 months, independent of multiple relevant covariates. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00847132.
Authors: Christopher M Celano; Ana C Villegas; Ariana M Albanese; Hanna K Gaggin; Jeff C Huffman Journal: Harv Rev Psychiatry Date: 2018 Jul/Aug Impact factor: 3.732
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Authors: Phillip J Tully; Deborah A Turnbull; John D Horowitz; John F Beltrame; Terina Selkow; Bernhard T Baune; Elizabeth Markwick; Shannon Sauer-Zavala; Harald Baumeister; Suzanne Cosh; Gary A Wittert Journal: Trials Date: 2016-01-11 Impact factor: 2.279
Authors: Amir Vahedian-Azimi; Andrew C Miller; Mohammadreza Hajiesmaieli; Mari Kangasniemi; Fatemah Alhani; Hosseinali Jelvehmoghaddam; Mohammad Fathi; Behrooz Farzanegan; Seyed H Ardehali; Sevak Hatamian; Mehdi Gahremani; Seyed M M Mosavinasab; Zohreh Rostami; Seyed J Madani; Morteza Izadi Journal: Open Heart Date: 2016-04-19