| Literature DB >> 22209051 |
Li-Ling Wang1, Yue Huang, Gang Wang, Sheng-Di Chen.
Abstract
Recently, there have been increasing evidences that microRNA-146 (miR-146) is related to up-regulated immune and inflammatory signaling through its target genes, such as IRAK1 and TRAF6. Additionally, abundant data continue to support the hypothesis that progressive up-regulation of inflammatory gene expression and elevated inflammatory signaling facilitate the development and progression of Alzheimer's disease (AD). This review focuses on the recent findings regarding the role of miR-146 in modulating immune response and its subsequent effects in the pathogenesis of AD.Entities:
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Year: 2011 PMID： 22209051 DOI： 10.1016/j.mehy.2011.11.019
Source DB: PubMed Journal: Med Hypotheses ISSN： 0306-9877 Impact factor: 1.538