AIMS: We determined levels of the inflammatory marker YKL-40 in a population of patients with type 2 diabetes (T2D) and investigated the association with mortality. METHODS: In a prospective observational follow-up study, 290 patients with T2D, normoalbuminuria (n=177), microalbuminuria (n=71) and macroalbuminuria (n=42) were followed for a median (range) of 17.2 (0.2-23.0) years. Serum YKL-40 concentration was determined at baseline. RESULTS: Baseline median (IQR) YKL-40 level was 46ng/ml (36-67) in patients with normoalbuminuria, 61ng/ml (43-114) in microalbuminuric patients, and 81.5ng/ml (60-157) in patients with macroalbuminuria, p<0.001. During follow-up 189 patients (65.2%) died, 119 (41.0%) from cardiovascular causes. All-cause mortality was increased in patients with YKL-40 levels in the second and third tertile (hazard ratios (95% CI) compared with the first tertile, (1.50 (1.03-2.19), p=0.034, and 2.88 (2.01-4.12), p<0.001). This association persisted after adjustment for cardiovascular risk factors but was attenuated after additional adjustment for urinary albumin excretion rate and glomerular filtration rate. Cardiovascular mortality was increased with YKL-40 levels in the third tertile compared with the first tertile, (2.70 (1.78-4.08)), p<0.001. This association was diminished after adjustment for covariates. CONCLUSIONS: In patients with T2D and increasing albuminuria high YKL-40 levels predict all-cause mortality.
AIMS: We determined levels of the inflammatory marker YKL-40 in a population of patients with type 2 diabetes (T2D) and investigated the association with mortality. METHODS: In a prospective observational follow-up study, 290 patients with T2D, normoalbuminuria (n=177), microalbuminuria (n=71) and macroalbuminuria (n=42) were followed for a median (range) of 17.2 (0.2-23.0) years. Serum YKL-40 concentration was determined at baseline. RESULTS: Baseline median (IQR) YKL-40 level was 46ng/ml (36-67) in patients with normoalbuminuria, 61ng/ml (43-114) in microalbuminuric patients, and 81.5ng/ml (60-157) in patients with macroalbuminuria, p<0.001. During follow-up 189 patients (65.2%) died, 119 (41.0%) from cardiovascular causes. All-cause mortality was increased in patients with YKL-40 levels in the second and third tertile (hazard ratios (95% CI) compared with the first tertile, (1.50 (1.03-2.19), p=0.034, and 2.88 (2.01-4.12), p<0.001). This association persisted after adjustment for cardiovascular risk factors but was attenuated after additional adjustment for urinary albumin excretion rate and glomerular filtration rate. Cardiovascular mortality was increased with YKL-40 levels in the third tertile compared with the first tertile, (2.70 (1.78-4.08)), p<0.001. This association was diminished after adjustment for covariates. CONCLUSIONS: In patients with T2D and increasing albuminuria high YKL-40 levels predict all-cause mortality.
Authors: Michelle J Pena; Andreas Heinzel; Georg Heinze; Alaa Alkhalaf; Stephan J L Bakker; Tri Q Nguyen; Roel Goldschmeding; Henk J G Bilo; Paul Perco; Bernd Mayer; Dick de Zeeuw; Hiddo J Lambers Heerspink Journal: PLoS One Date: 2015-05-14 Impact factor: 3.240
Authors: Andrea L Conroy; Michael T Hawkes; Robyn Elphinstone; Robert O Opoka; Sophie Namasopo; Christopher Miller; Chandy C John; Kevin C Kain Journal: Malar J Date: 2018-02-15 Impact factor: 2.979
Authors: Dennis B Holmgaard; Lone H Mygind; Ingrid L Titlestad; Hanne Madsen; Svend Stenvang Pedersen; Julia S Johansen; Court Pedersen Journal: BMC Pulm Med Date: 2013-12-30 Impact factor: 3.317