| Literature DB >> 22208983 |
Sang-Kyung Lee1, Alyssa Siefert, Jagadish Beloor, Tarek M Fahmy, Priti Kumar.
Abstract
Cellular targeting and intracellular delivery of small interfering RNA (siRNA) remain a critical barrier to the clinical application of RNA interference. This chapter provides an overview of various delivery agents employing protein ligands mediating cell-specific delivery of siRNA. Specifically, the chapter details methodologies for the conjugation of antibody or peptide ligands to i) the cationic peptide-oligo-9-arginine (ii) the polymer poly(lactic-co-glycolic acid) (PLGA) and (iii) a lipid-vesicle (liposome).Entities:
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Year: 2012 PMID： 22208983 DOI： 10.1016/B978-0-12-416039-2.00005-7
Source DB: PubMed Journal: Methods Enzymol ISSN： 0076-6879 Impact factor: 1.600