Dermatologic manifestations of hepatitis C infection and the effect of interferon therapy: a literature review.

The skin could be a main target organ for extrahepatic manifestations in hepatitis C virus- (HCV) infected patients and research data suggest that interferon treatment may be associated with immune-mediated skin lesions. However, case reports propose that the response of dermatologic extrahepatic manifestations to interferon in patients with chronic HCV is greatly different. The objective of this study is to summarize currently available data on dermatologic conditions associated with chronic HCV infection. In addition, we investigate the incidence of the development of immune mediated dermatologic disorders during interferon therapy in these patients.