INTRODUCTION: Type 2 diabetes (T2D) candidate gene: potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) was suggested by conducting a genome wide association study (GWAS) in Japanese population. Association studies have been replicated among East Asian populations; however, the association between this gene and T2D in Southeast Asian populations still needs to be studied. This study aimed to investigate the association of KCNQ1 common variants with type 2 diabetes in Malaysian Malay subjects. MATERIALS AND METHODS: The KCNQ1 single nucleotide polymorphisms (SNPs): rs2237892, rs2283228, and rs2237895 were genotyped in 234 T2D and 177 normal Malay subjects. RESULTS: The risk allele of the rs2283228 (A) was strongly associated with T2D (OR = 1.7, P = 0.0006) while the rs2237892 (C) was moderately associated with T2D (OR = 1.45, P = 0.017). The recessive genetic models showed that rs2283228 was strongly associated with T2D (OR = 2.35, P = 0.00005) whereas rs2237892 showed a moderate association with T2D (OR = 1.69, P = 0.01). The haplotype block (TCA), which contained the protective allele, correlated with a protection from T2D (OR = 0.5, P = 0.003). Furthermore, the diplotype (CAA-TCA) that contained the protective haplotype was protected against T2D (OR = 0.46, P = 0.006). CONCLUSION: The KCNQ1 SNPs, haplotypes and diplotypes are associated with T2D in the Malaysian Malay subjects.
INTRODUCTION:Type 2 diabetes (T2D) candidate gene: potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) was suggested by conducting a genome wide association study (GWAS) in Japanese population. Association studies have been replicated among East Asian populations; however, the association between this gene and T2D in Southeast Asian populations still needs to be studied. This study aimed to investigate the association of KCNQ1 common variants with type 2 diabetes in Malaysian Malay subjects. MATERIALS AND METHODS: The KCNQ1 single nucleotide polymorphisms (SNPs): rs2237892, rs2283228, and rs2237895 were genotyped in 234 T2D and 177 normal Malay subjects. RESULTS: The risk allele of the rs2283228 (A) was strongly associated with T2D (OR = 1.7, P = 0.0006) while the rs2237892 (C) was moderately associated with T2D (OR = 1.45, P = 0.017). The recessive genetic models showed that rs2283228 was strongly associated with T2D (OR = 2.35, P = 0.00005) whereas rs2237892 showed a moderate association with T2D (OR = 1.69, P = 0.01). The haplotype block (TCA), which contained the protective allele, correlated with a protection from T2D (OR = 0.5, P = 0.003). Furthermore, the diplotype (CAA-TCA) that contained the protective haplotype was protected against T2D (OR = 0.46, P = 0.006). CONCLUSION: The KCNQ1 SNPs, haplotypes and diplotypes are associated with T2D in the Malaysian Malay subjects.
Authors: V M H Tan; Y S Lee; K Venkataraman; E Y H Khoo; E S Tai; Y S Chong; P Gluckman; M K S Leow; C M Khoo Journal: Nutr Diabetes Date: 2015-07-20 Impact factor: 5.097
Authors: Julian A Schreiber; Melina Möller; Mark Zaydman; Lu Zhao; Zachary Beller; Sebastian Becker; Nadine Ritter; Panpan Hou; Jingyi Shi; Jon Silva; Eva Wrobel; Nathalie Strutz-Seebohm; Niels Decher; Nicole Schmitt; Sven G Meuth; Martina Düfer; Bernhard Wünsch; Jianmin Cui; Guiscard Seebohm Journal: Commun Biol Date: 2022-04-01
Authors: Kylee L Spencer; Jennifer Malinowski; Cara L Carty; Nora Franceschini; Lindsay Fernández-Rhodes; Alicia Young; Iona Cheng; Marylyn D Ritchie; Christopher A Haiman; Lynne Wilkens; Tara C Matise; Christopher S Carlson; Kathleen Brennan; Amy Park; Aleksandar Rajkovic; Lucia A Hindorff; Steven Buyske; Dana C Crawford Journal: PLoS One Date: 2013-02-12 Impact factor: 3.240