OBJECTIVES: To investigate associations between autoimmune disorders and Parkinson disease (PD), and to study whether the risk is associated with follow-up time and age. METHODS: Standardized incidence ratios (SIRs) were calculated for PD in patients with autoimmune disorders by comparing them to subjects without autoimmune disorders. RESULTS: Among 310,522 patients with a total of 33 conditions of autoimmune disorders, 932 patients developed subsequent PD, giving an overall SIR of 1.33 and 1.19 for PD diagnosed later than 1 year after follow-up. Six types of autoimmune disorders showed an increased risk. These conditions included: amyotrophic lateral sclerosis, Graves's disease/hyperthyroidism, Hashimoto's disease/hypothyroidism, multiple sclerosis, pernicious anemia, and polymyalgia rheumatica. The risks depended on the age at hospitalization for PD. CONCLUSIONS: A 33% overall excess risk of PD was noted among patients with an autoimmune disorder; the risk was increased during the first 10 years of follow-up after hospitalization of autoimmune disorders.
OBJECTIVES: To investigate associations between autoimmune disorders and Parkinson disease (PD), and to study whether the risk is associated with follow-up time and age. METHODS: Standardized incidence ratios (SIRs) were calculated for PD in patients with autoimmune disorders by comparing them to subjects without autoimmune disorders. RESULTS: Among 310,522 patients with a total of 33 conditions of autoimmune disorders, 932 patients developed subsequent PD, giving an overall SIR of 1.33 and 1.19 for PD diagnosed later than 1 year after follow-up. Six types of autoimmune disorders showed an increased risk. These conditions included: amyotrophic lateral sclerosis, Graves's disease/hyperthyroidism, Hashimoto's disease/hypothyroidism, multiple sclerosis, pernicious anemia, and polymyalgia rheumatica. The risks depended on the age at hospitalization for PD. CONCLUSIONS: A 33% overall excess risk of PD was noted among patients with an autoimmune disorder; the risk was increased during the first 10 years of follow-up after hospitalization of autoimmune disorders.
Authors: Maria D Chikina; Christophe P Gerald; Xianting Li; Yongchao Ge; Hanna Pincas; Venugopalan D Nair; Aaron K Wong; Arjun Krishnan; Olga G Troyanskaya; Deborah Raymond; Rachel Saunders-Pullman; Susan B Bressman; Zhenyu Yue; Stuart C Sealfon Journal: Mov Disord Date: 2015-03-18 Impact factor: 10.338
Authors: Aree Witoelar; Iris E Jansen; Yunpeng Wang; Rahul S Desikan; J Raphael Gibbs; Cornelis Blauwendraat; Wesley K Thompson; Dena G Hernandez; Srdjan Djurovic; Andrew J Schork; Francesco Bettella; David Ellinghaus; Andre Franke; Benedicte A Lie; Linda K McEvoy; Tom H Karlsen; Suzanne Lesage; Huw R Morris; Alexis Brice; Nicholas W Wood; Peter Heutink; John Hardy; Andrew B Singleton; Anders M Dale; Thomas Gasser; Ole A Andreassen; Manu Sharma Journal: JAMA Neurol Date: 2017-07-01 Impact factor: 18.302