Literature DB >> 22202030

The neuroprotective effects of apocynin.

Agnes Simonyi1, Peter Serfozo, Tareq M Lehmidi, Jiankun Cui, Zezong Gu, Dennis B Lubahn, Albert Y Sun, Grace Y Sun.   

Abstract

The recognition of health benefits of phytomedicines and herbal supplements lead to an increased interest to understand the cellular and molecular basis of their biological activities. Apocynin (4-hydroxy-3-methoxy-acetophenone) is a constituent of the Himalayan medicinal herb Picrorhiza kurroa which is regarded as an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, a superoxide-producing enzyme. NADPH oxidase appears to be especially important in the modulation of redox-sensitive signaling pathways and also has been implicated in neuronal dysfunction and degeneration, and neuroinflammmation in diseases ranging from stroke, Alzheimer's and Parkinson's diseases to psychiatric disorders. In this review, we aim to give an overview of current literature on the neuroprotective effects of apocynin in the prevention and treatment of neurodegenerative disorders. Particular attention is given to in vivo studies.

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Year:  2012        PMID： 22202030      PMCID： PMC4049349          DOI： 10.2741/535

Source DB:  PubMed          Journal:  Front Biosci (Elite Ed)        ISSN： 1945-0494


  112 in total

1.  NADPH oxidase-mediated oxidative damage to proteins in the postsynaptic density after transient cerebral ischemia and reperfusion.

Authors:  Kazutoshi Murotomi; Norio Takagi; Satoshi Takeo; Kouichi Tanonaka
Journal:  Mol Cell Neurosci       Date:  2011-01-22       Impact factor: 4.314

Review 2.  The neuropathogenesis of AIDS.

Authors:  Francisco González-Scarano; Julio Martín-García
Journal:  Nat Rev Immunol       Date:  2005-01       Impact factor: 53.106

3.  Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils.

Authors:  J M Simons; B A Hart; T R Ip Vai Ching; H Van Dijk; R P Labadie
Journal:  Free Radic Biol Med       Date:  1990       Impact factor: 7.376

4.  Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease.

Authors:  Wei Zhang; Kester Phillips; Albert R Wielgus; Jie Liu; Alberto Albertini; Fabio A Zucca; Rudolph Faust; Steven Y Qian; David S Miller; Colin F Chignell; Belinda Wilson; Vernice Jackson-Lewis; Serge Przedborski; Danielle Joset; John Loike; Jau-Shyong Hong; David Sulzer; Luigi Zecca
Journal:  Neurotox Res       Date:  2009-12-03       Impact factor: 3.911

Review 5.  Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities.

Authors:  Rao Muralikrishna Adibhatla; James Franklin Hatcher
Journal:  Antioxid Redox Signal       Date:  2010-01       Impact factor: 8.401

6.  Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease.

Authors:  Arundhati Jana; Kalipada Pahan
Journal:  J Biol Chem       Date:  2004-09-27       Impact factor: 5.157

7.  Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease.

Authors:  Hui-Ming Gao; Bin Liu; Wanqin Zhang; Jau-Shyong Hong
Journal:  FASEB J       Date:  2003-08-01       Impact factor: 5.191

8.  SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model.

Authors:  Maged M Harraz; Jennifer J Marden; Weihong Zhou; Yulong Zhang; Aislinn Williams; Victor S Sharov; Kathryn Nelson; Meihui Luo; Henry Paulson; Christian Schöneich; John F Engelhardt
Journal:  J Clin Invest       Date:  2008-02       Impact factor: 14.808

9.  Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo.

Authors:  Boris Görg; Natalia Qvartskhava; Verena Keitel; Hans J Bidmon; Oliver Selbach; Freimut Schliess; Dieter Häussinger
Journal:  Hepatology       Date:  2008-08       Impact factor: 17.425

10.  A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia.

Authors:  Zezong Gu; Jiankun Cui; Stephen Brown; Rafael Fridman; Shahriar Mobashery; Alex Y Strongin; Stuart A Lipton
Journal:  J Neurosci       Date:  2005-07-06       Impact factor: 6.709
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  20 in total

1.  Neuroprotective Effects of Apocynin and Galantamine During the Chronic Administration of Scopolamine in an Alzheimer's Disease Model.

Authors:  Eliezer Joseph; Daniel Miguel Ángel Villalobos-Acosta; Mónica Adriana Torres-Ramos; Eunice Dalet Farfán-García; Modesto Gómez-López; Ángel Miliar-García; Manuel Jonathan Fragoso-Vázquez; Iohanan Daniel García-Marín; José Correa-Basurto; Martha Cecilia Rosales-Hernández
Journal:  J Mol Neurosci       Date:  2019-11-25       Impact factor: 3.444

Review 2.  Integrating cytosolic phospholipase A₂ with oxidative/nitrosative signaling pathways in neurons: a novel therapeutic strategy for AD.

Authors:  Grace Y Sun; Yan He; Dennis Y Chuang; James C Lee; Zezong Gu; Agnes Simonyi; Albert Y Sun
Journal:  Mol Neurobiol       Date:  2012-04-03       Impact factor: 5.590

3.  Histopathological and ophthalmoscopic evaluation of apocynin on experimental proliferative vitreoretinopathy in rabbit eyes.

Authors:  Murat Atabey Ozer; Nihat Polat; Serkan Ozen; Tevfik Ogurel; Hakan Parlakpinar; Nigar Vardi
Journal:  Int Ophthalmol       Date:  2016-08-05       Impact factor: 2.031

4.  Apocynin prevents isoproterenol-induced cardiac hypertrophy in rat.

Authors:  Nikhat Saleem; Anamika Prasad; Shyamal K Goswami
Journal:  Mol Cell Biochem       Date:  2017-12-18       Impact factor: 3.396

5.  Mitoapocynin, a mitochondria targeted derivative of apocynin induces mitochondrial ROS generation and apoptosis in multiple cell types including cardiac myoblasts: a potential constraint to its therapeutic use.

Authors:  Amena Mahmood; Padmini Bisoyi; Rajkumar Banerjee; Md Yousuf; Shyamal K Goswami
Journal:  Mol Cell Biochem       Date:  2021-01-30       Impact factor: 3.396

Review 6.  Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress.

Authors:  Kim A Radermacher; Kirstin Wingler; Friederike Langhauser; Sebastian Altenhöfer; Pamela Kleikers; J J Rob Hermans; Martin Hrabě de Angelis; Christoph Kleinschnitz; Harald H H W Schmidt
Journal:  Antioxid Redox Signal       Date:  2012-10-16       Impact factor: 8.401

7.  Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.

Authors:  Monica Langley; Anamitra Ghosh; Adhithiya Charli; Souvarish Sarkar; Muhammet Ay; Jie Luo; Jacek Zielonka; Timothy Brenza; Brian Bennett; Huajun Jin; Shivani Ghaisas; Benjamin Schlichtmann; Dongsuk Kim; Vellareddy Anantharam; Arthi Kanthasamy; Balaji Narasimhan; Balaraman Kalyanaraman; Anumantha G Kanthasamy
Journal:  Antioxid Redox Signal       Date:  2017-04-04       Impact factor: 8.401

8.  Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R¹⁴⁴¹G) transgenic mouse.

Authors:  Brian P Dranka; Alison Gifford; Anamitra Ghosh; Jacek Zielonka; Joy Joseph; Anumantha G Kanthasamy; Balaraman Kalyanaraman
Journal:  Neurosci Lett       Date:  2013-05-28       Impact factor: 3.046

Review 9.  Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration.

Authors:  Shih-Heng Chen; Esteban A Oyarzabal; Jau-Shyong Hong
Journal:  Curr Opin Pharmacol       Date:  2015-10-26       Impact factor: 5.547

10.  Improvement of pro-oxidant capacity of protocatechuic acid by esterification.

Authors:  Maria Luiza Zeraik; Maicon S Petrônio; Dyovani Coelho; Luis Octavio Regasini; Dulce H S Silva; Luiz Marcos da Fonseca; Sergio A S Machado; Vanderlan S Bolzani; Valdecir F Ximenes
Journal:  PLoS One       Date:  2014-10-23       Impact factor: 3.240
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