Literature DB >> 22200613

Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells.

Michaele J Armstrong1, Michael T Stang, Ye Liu, Jinbo Gao, Baoguo Ren, Brian S Zuckerbraun, Raja S Mahidhara, Quanhua Xing, Eva Pizzoferrato, John H Yim.   

Abstract

We have shown that the ectopic expression of Interferon Regulatory Factor 1 (IRF-1) results in human cancer cell death accompanied by the down-regulation of the Inhibitor of Apoptosis Protein (IAP) survivin and the induction of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1). In this report, we investigated the direct role of p21 in the suppression of survivin. We show that IRF-1 down-regulates cyclin B1, cdc-2, cyclin E, E2F1, Cdk2, Cdk4, and results in p21-mediated G1 cell cycle arrest. Interestingly, while p21 directly mediates G1 cell cycle arrest, IRF-1 or other IRF-1 signaling pathways may directly regulate survivin in human cancer cells.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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Year:  2011        PMID： 22200613      PMCID： PMC3304016          DOI： 10.1016/j.canlet.2011.12.027

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  70 in total

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Journal:  Front Biosci       Date:  1998-04-27

Review 2.  Cyclin B1 and CDK1: nuclear localization and upstream regulators.

Authors:  Lisa A Porter; Daniel J Donoghue
Journal:  Prog Cell Cycle Res       Date:  2003

3.  Tetra-O-methyl nordihydroguaiaretic acid induces growth arrest and cellular apoptosis by inhibiting Cdc2 and survivin expression.

Authors:  Chih-Chuan Chang; Jonathan D Heller; Jennifer Kuo; Ru Chih C Huang
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5.  Survivin expression predicts poorer prognosis in anaplastic large-cell lymphoma.

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Journal:  Oncogene       Date:  2004-09-02       Impact factor: 9.867

7.  Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells.

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9.  IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo.

Authors:  Peter K M Kim; Michaele Armstrong; Ye Liu; Peng Yan; Brian Bucher; Brian S Zuckerbraun; Andrea Gambotto; Timothy R Billiar; John H Yim
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10.  Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo.

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  17 in total

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Authors:  Michaele J Armstrong; Michael T Stang; Ye Liu; Jin Yan; Eva Pizzoferrato; John H Yim
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2.  PKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cells.

Authors:  Xiangfei Liu; Richard L Bennett; Xiaodong Cheng; Michael Byrne; Mary K Reinhard; W Stratford May
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3.  Tumor suppressor Interferon Regulatory Factor 1 selectively blocks expression of endogenous retrovirus.

Authors:  K P Stoltz; C N Jondle; K Pulakanti; P A Sylvester; R Urrutia; S Rao; V L Tarakanova
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4.  The local environment orchestrates mucosal decidual macrophage differentiation and substantially inhibits HIV-1 replication.

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Journal:  Mucosal Immunol       Date:  2015-09-09       Impact factor: 7.313

5.  IRF-1 regulates alternative mRNA splicing of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in breast epithelial cells generating an immunoreceptor tyrosine-based inhibition motif (ITIM) containing isoform.

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6.  Tissue Inhibitor of Matrix Metalloproteinases-1 Knockdown Suppresses the Proliferation of Human Adipose-Derived Stem Cells.

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7.  RelA-Induced Interferon Response Negatively Regulates Proliferation.

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8.  MicroRNA-23a downregulates the expression of interferon regulatory factor-1 in hepatocellular carcinoma cells.

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9.  Knockdown of High Mobility Group-Box 3 (HMGB3) Expression Inhibits Proliferation, Reduces Migration, and Affects Chemosensitivity in Gastric Cancer Cells.

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10.  Bi-directional roles of IRF-1 on autophagy diminish its prognostic value as compared with Ki67 in liver transplantation for hepatocellular carcinoma.

Authors:  Hai-Ming Zhang; Shi-Peng Li; Yao Yu; Zhen Wang; Jin-Dan He; Yan-Jie Xu; Rong-Xin Zhang; Jian-Jun Zhang; Zhi-Jun Zhu; Zhong-Yang Shen
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