| Literature DB >> 22200404 |
Lihong Ning1, Wei Wang, Yongju Liang, Hao Peng, Liwu Fu, Hongwu He.
Abstract
A series of O,O'-dialkyl {[2-(substituted phenoxy)acetamido](substituted phenyl)methyl}phosphonates was synthesized and their cytotoxic activities were tested against various human tumor cell lines. Some compounds (5q, 5r, 5s, 5w, 5x and 5y) showed relatively high cytotoxicity. Especially, compounds 5x and 5q exhibited the best cytotoxicity against KB and CNE2 cells with IC(50) 7.1 and 11.4 μM, respectively. Their inhibitory activities against KB and CNE2 cells were even higher than that of fluorouracil.Entities:
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Year: 2011 PMID： 22200404 DOI： 10.1016/j.ejmech.2011.12.014
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514