Ethyl 4-acetamido-3-acet-oxy-2-benzyl-3-methyl-butano-ate.

The crystal structure of the title compound, C(18)H(25)NO(5), is stabilized by inter-molecular N-H⋯O hydrogen bonds, which form inversion dimers. The ethyl group is disordered over two positions in a 0.651 (12):0.349 (12) ratio.

Related literature

For the pharmacological activity of pyrrolidin-2-one compounds, see: Ichikawa & Kato (2001 ▶). For applications of related compounds, see: De Clercq (2004 ▶); Ge et al. (2009 ▶, 2011 ▶). The synthesis of the title compound was adapted from literature procedures for the preparation of closely related compounds, see: Bishop et al. (1991 ▶).

Experimental

Crystal data

C18H25NO5

M = 335.39

Triclinic,

a = 9.7995 (18) Å

b = 10.0340 (19) Å

c = 10.481 (2) Å

α = 100.571 (3)°

β = 105.350 (3)°

γ = 107.957 (3)°

V = 905.1 (3) Å3

Z = 2

Mo Kα radiation

μ = 0.09 mm−1

T = 293 K

0.24 × 0.19 × 0.16 mm

Data collection

Bruker SMART APEXII diffractometer

Absorption correction: multi-scan (SADABS; Bruker, 2005 ▶) T min = 0.979, T max = 0.986

4623 measured reflections

3167 independent reflections

2598 reflections with I > 2σ(I)

R int = 0.016

Refinement

R[F 2 > 2σ(F 2)] = 0.045

wR(F 2) = 0.138

S = 1.06

3167 reflections

236 parameters

2 restraints

H-atom parameters constrained

Δρmax = 0.20 e Å−3

Δρmin = −0.19 e Å−3

Data collection: SMART (Bruker, 2005 ▶); cell refinement: SAINT (Bruker, 2005 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: XP in SHELXTL (Sheldrick, 2008 ▶); software used to prepare material for publication: SHELXL97.

Crystal structure: contains datablock(s) I, global. DOI: 10.1107/S1600536811049440/fy2028sup1.cif

Structure factors: contains datablock(s) I. DOI: 10.1107/S1600536811049440/fy2028Isup2.hkl

Supplementary material file. DOI: 10.1107/S1600536811049440/fy2028Isup3.cml

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C18H25NO5	Z = 2
Mr = 335.39	F(000) = 360
Triclinic, P1	Dx = 1.231 Mg m−3
Hall symbol: -P 1	Mo Kα radiation, λ = 0.71073 Å
a = 9.7995 (18) Å	Cell parameters from 2878 reflections
b = 10.0340 (19) Å	θ = 2.6–28.3°
c = 10.481 (2) Å	µ = 0.09 mm−1
α = 100.571 (3)°	T = 293 K
β = 105.350 (3)°	Block, colorless
γ = 107.957 (3)°	0.24 × 0.19 × 0.16 mm
V = 905.1 (3) Å3

Bruker SMART APEXII diffractometer	3167 independent reflections
Radiation source: fine-focus sealed tube	2598 reflections with I > 2σ(I)
graphite	Rint = 0.016
φ and ω scans	θmax = 25.1°, θmin = 2.1°
Absorption correction: multi-scan (SADABS; Bruker, 2005)	h = −10→11
Tmin = 0.979, Tmax = 0.986	k = −11→10
4623 measured reflections	l = −10→12

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.045	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.138	H-atom parameters constrained
S = 1.06	w = 1/[σ2(Fo2) + (0.0739P)2 + 0.2116P] where P = (Fo2 + 2Fc2)/3
3167 reflections	(Δ/σ)max < 0.001
236 parameters	Δρmax = 0.20 e Å−3
2 restraints	Δρmin = −0.19 e Å−3

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq	Occ. (<1)
O1	0.14359 (19)	0.04705 (16)	0.78101 (19)	0.0813 (5)
O2	0.34401 (17)	0.22351 (16)	0.77960 (16)	0.0650 (4)
O3	0.20424 (15)	0.64375 (16)	1.02379 (13)	0.0606 (4)
O4	−0.09510 (15)	0.32515 (17)	0.46869 (13)	0.0614 (4)
O5	0.09310 (13)	0.29479 (13)	0.62267 (11)	0.0451 (3)
N1	0.12798 (17)	0.57192 (15)	0.79270 (15)	0.0456 (4)
H1	0.1480	0.5898	0.7211	0.055*
C1	0.2615 (2)	0.1673 (2)	1.1462 (2)	0.0556 (5)
H1A	0.1808	0.0775	1.1024	0.067*
C2	0.3832 (3)	0.1795 (3)	1.2567 (2)	0.0675 (6)
H2	0.3837	0.0982	1.2872	0.081*
C3	0.5025 (3)	0.3099 (3)	1.3211 (2)	0.0696 (6)
H3	0.5837	0.3183	1.3963	0.083*
C4	0.5024 (3)	0.4290 (3)	1.2746 (2)	0.0750 (7)
H4	0.5849	0.5178	1.3168	0.090*
C5	0.3802 (2)	0.4171 (2)	1.1653 (2)	0.0636 (6)
H5	0.3804	0.4988	1.1353	0.076*
C6	0.25803 (19)	0.28698 (19)	1.09999 (17)	0.0442 (4)
C7	0.1239 (2)	0.2751 (2)	0.98167 (18)	0.0494 (4)
H7A	0.0849	0.3488	1.0111	0.059*
H7B	0.0434	0.1799	0.9579	0.059*
C8	0.16401 (18)	0.29482 (18)	0.85328 (16)	0.0397 (4)
H8	0.2507	0.3879	0.8806	0.048*
C9	0.2136 (2)	0.1739 (2)	0.80042 (18)	0.0481 (4)
C10	0.4408 (12)	0.1485 (12)	0.7559 (10)	0.060 (2)	0.349 (12)
H10A	0.4094	0.0537	0.7727	0.072*	0.349 (12)
H10B	0.5466	0.2054	0.8134	0.072*	0.349 (12)
C11	0.417 (2)	0.1330 (19)	0.6029 (7)	0.106 (5)	0.349 (12)
H11A	0.4724	0.0766	0.5728	0.159*	0.349 (12)
H11B	0.4546	0.2283	0.5902	0.159*	0.349 (12)
H11C	0.3106	0.0844	0.5496	0.159*	0.349 (12)
C10'	0.3713 (8)	0.0989 (6)	0.7031 (7)	0.0680 (14)	0.651 (12)
H10C	0.2790	0.0317	0.6284	0.082*	0.651 (12)
H10D	0.4071	0.0459	0.7644	0.082*	0.651 (12)
C11'	0.4937 (6)	0.1734 (7)	0.6475 (8)	0.0788 (16)	0.651 (12)
H11D	0.5166	0.1006	0.5934	0.118*	0.651 (12)
H11E	0.5844	0.2377	0.7232	0.118*	0.651 (12)
H11F	0.4574	0.2288	0.5907	0.118*	0.651 (12)
C12	0.03185 (18)	0.29931 (18)	0.73647 (16)	0.0411 (4)
C13	−0.1161 (2)	0.1694 (2)	0.6960 (2)	0.0583 (5)
H13A	−0.1894	0.1721	0.6160	0.087*
H13B	−0.1549	0.1730	0.7711	0.087*
H13C	−0.0978	0.0805	0.6753	0.087*
C14	0.00377 (19)	0.43993 (19)	0.77358 (18)	0.0441 (4)
H14A	−0.0853	0.4337	0.7010	0.053*
H14B	−0.0202	0.4466	0.8580	0.053*
C15	0.2144 (2)	0.66885 (19)	0.91664 (18)	0.0455 (4)
C16	0.3241 (3)	0.8094 (2)	0.9149 (3)	0.0736 (6)
H16A	0.3159	0.8900	0.9735	0.110*
H16B	0.3006	0.8168	0.8221	0.110*
H16C	0.4263	0.8118	0.9478	0.110*
C17	0.0227 (2)	0.30512 (19)	0.49921 (17)	0.0458 (4)
C18	0.1100 (2)	0.2895 (2)	0.4059 (2)	0.0604 (5)
H18A	0.0421	0.2542	0.3117	0.091*
H18B	0.1576	0.2214	0.4248	0.091*
H18C	0.1871	0.3829	0.4205	0.091*

	U11	U22	U33	U12	U13	U23
O1	0.0832 (11)	0.0437 (9)	0.1075 (13)	0.0247 (8)	0.0207 (9)	0.0160 (8)
O2	0.0795 (10)	0.0686 (9)	0.0821 (10)	0.0499 (8)	0.0469 (8)	0.0361 (8)
O3	0.0617 (8)	0.0703 (9)	0.0423 (7)	0.0166 (7)	0.0156 (6)	0.0170 (6)
O4	0.0585 (8)	0.0872 (10)	0.0472 (7)	0.0395 (7)	0.0129 (6)	0.0261 (7)
O5	0.0458 (6)	0.0549 (7)	0.0351 (6)	0.0234 (5)	0.0093 (5)	0.0134 (5)
N1	0.0576 (9)	0.0473 (8)	0.0414 (8)	0.0242 (7)	0.0216 (7)	0.0202 (7)
C1	0.0547 (11)	0.0570 (11)	0.0591 (11)	0.0200 (9)	0.0188 (9)	0.0288 (9)
C2	0.0691 (13)	0.0815 (15)	0.0728 (14)	0.0394 (12)	0.0256 (11)	0.0492 (13)
C3	0.0580 (12)	0.0973 (17)	0.0556 (12)	0.0329 (12)	0.0100 (10)	0.0346 (12)
C4	0.0666 (13)	0.0727 (15)	0.0606 (13)	0.0128 (11)	−0.0015 (10)	0.0196 (11)
C5	0.0710 (13)	0.0523 (11)	0.0555 (12)	0.0195 (10)	0.0042 (10)	0.0209 (9)
C6	0.0472 (9)	0.0517 (10)	0.0408 (9)	0.0221 (8)	0.0176 (7)	0.0198 (8)
C7	0.0453 (9)	0.0615 (11)	0.0456 (10)	0.0214 (8)	0.0150 (8)	0.0239 (8)
C8	0.0369 (8)	0.0409 (9)	0.0387 (9)	0.0138 (7)	0.0082 (7)	0.0143 (7)
C9	0.0532 (10)	0.0453 (10)	0.0443 (9)	0.0222 (8)	0.0088 (8)	0.0150 (8)
C10	0.048 (5)	0.059 (5)	0.075 (5)	0.031 (4)	0.016 (4)	0.015 (4)
C11	0.114 (11)	0.117 (10)	0.075 (7)	0.068 (9)	0.013 (6)	−0.013 (6)
C10'	0.077 (4)	0.066 (3)	0.067 (3)	0.044 (3)	0.023 (3)	0.008 (2)
C11'	0.077 (3)	0.097 (4)	0.070 (4)	0.049 (3)	0.030 (3)	0.006 (3)
C12	0.0387 (8)	0.0464 (9)	0.0373 (9)	0.0158 (7)	0.0100 (7)	0.0149 (7)
C13	0.0433 (10)	0.0572 (12)	0.0586 (12)	0.0088 (8)	0.0041 (8)	0.0177 (9)
C14	0.0416 (8)	0.0548 (10)	0.0401 (9)	0.0232 (8)	0.0124 (7)	0.0167 (8)
C15	0.0493 (9)	0.0478 (10)	0.0470 (10)	0.0243 (8)	0.0195 (8)	0.0166 (8)
C16	0.0885 (16)	0.0507 (12)	0.0764 (15)	0.0144 (11)	0.0349 (13)	0.0171 (11)
C17	0.0492 (10)	0.0450 (10)	0.0377 (9)	0.0187 (8)	0.0065 (7)	0.0098 (7)
C18	0.0680 (12)	0.0773 (14)	0.0436 (10)	0.0375 (11)	0.0182 (9)	0.0189 (9)

O1—C9	1.194 (2)	C8—H8	0.9800
O2—C9	1.313 (2)	C10—C11	1.531 (3)
O2—C10	1.423 (8)	C10—H10A	0.9700
O2—C10'	1.493 (5)	C10—H10B	0.9700
O3—C15	1.218 (2)	C11—H11A	0.9600
O4—C17	1.203 (2)	C11—H11B	0.9600
O5—C17	1.335 (2)	C11—H11C	0.9600
O5—C12	1.470 (2)	C10'—C11'	1.521 (3)
N1—C15	1.341 (2)	C10'—H10C	0.9700
N1—C14	1.434 (2)	C10'—H10D	0.9700
N1—H1	0.8600	C11'—H11D	0.9600
C1—C2	1.381 (3)	C11'—H11E	0.9600
C1—C6	1.381 (3)	C11'—H11F	0.9600
C1—H1A	0.9300	C12—C13	1.512 (2)
C2—C3	1.360 (3)	C12—C14	1.521 (2)
C2—H2	0.9300	C13—H13A	0.9600
C3—C4	1.371 (3)	C13—H13B	0.9600
C3—H3	0.9300	C13—H13C	0.9600
C4—C5	1.377 (3)	C14—H14A	0.9700
C4—H4	0.9300	C14—H14B	0.9700
C5—C6	1.371 (3)	C15—C16	1.493 (3)
C5—H5	0.9300	C16—H16A	0.9600
C6—C7	1.506 (2)	C16—H16B	0.9600
C7—C8	1.528 (2)	C16—H16C	0.9600
C7—H7A	0.9700	C17—C18	1.477 (3)
C7—H7B	0.9700	C18—H18A	0.9600
C8—C9	1.508 (2)	C18—H18B	0.9600
C8—C12	1.548 (2)	C18—H18C	0.9600
C9—O2—C10	128.9 (5)	H11A—C11—H11C	109.5
C9—O2—C10'	109.6 (2)	H11B—C11—H11C	109.5
C10—O2—C10'	28.2 (3)	O2—C10'—C11'	103.4 (4)
C17—O5—C12	123.96 (13)	O2—C10'—H10C	111.1
C15—N1—C14	123.26 (14)	C11'—C10'—H10C	111.1
C15—N1—H1	118.4	O2—C10'—H10D	111.1
C14—N1—H1	118.4	C11'—C10'—H10D	111.1
C2—C1—C6	120.78 (19)	H10C—C10'—H10D	109.0
C2—C1—H1A	119.6	C10'—C11'—H11D	109.5
C6—C1—H1A	119.6	C10'—C11'—H11E	109.5
C3—C2—C1	120.28 (19)	H11D—C11'—H11E	109.5
C3—C2—H2	119.9	C10'—C11'—H11F	109.5
C1—C2—H2	119.9	H11D—C11'—H11F	109.5
C2—C3—C4	119.68 (19)	H11E—C11'—H11F	109.5
C2—C3—H3	120.2	O5—C12—C13	110.07 (14)
C4—C3—H3	120.2	O5—C12—C14	110.82 (13)
C3—C4—C5	120.0 (2)	C13—C12—C14	109.41 (14)
C3—C4—H4	120.0	O5—C12—C8	101.15 (12)
C5—C4—H4	120.0	C13—C12—C8	113.50 (14)
C6—C5—C4	121.22 (19)	C14—C12—C8	111.67 (14)
C6—C5—H5	119.4	C12—C13—H13A	109.5
C4—C5—H5	119.4	C12—C13—H13B	109.5
C5—C6—C1	118.05 (17)	H13A—C13—H13B	109.5
C5—C6—C7	120.95 (16)	C12—C13—H13C	109.5
C1—C6—C7	121.00 (17)	H13A—C13—H13C	109.5
C6—C7—C8	113.01 (14)	H13B—C13—H13C	109.5
C6—C7—H7A	109.0	N1—C14—C12	115.47 (14)
C8—C7—H7A	109.0	N1—C14—H14A	108.4
C6—C7—H7B	109.0	C12—C14—H14A	108.4
C8—C7—H7B	109.0	N1—C14—H14B	108.4
H7A—C7—H7B	107.8	C12—C14—H14B	108.4
C9—C8—C7	109.42 (14)	H14A—C14—H14B	107.5
C9—C8—C12	109.97 (14)	O3—C15—N1	122.09 (16)
C7—C8—C12	113.48 (13)	O3—C15—C16	122.17 (18)
C9—C8—H8	107.9	N1—C15—C16	115.74 (17)
C7—C8—H8	107.9	C15—C16—H16A	109.5
C12—C8—H8	107.9	C15—C16—H16B	109.5
O1—C9—O2	123.37 (18)	H16A—C16—H16B	109.5
O1—C9—C8	124.07 (18)	C15—C16—H16C	109.5
O2—C9—C8	112.55 (15)	H16A—C16—H16C	109.5
O2—C10—C11	101.9 (8)	H16B—C16—H16C	109.5
O2—C10—H10A	111.4	O4—C17—O5	124.54 (17)
C11—C10—H10A	111.4	O4—C17—C18	124.82 (16)
O2—C10—H10B	111.4	O5—C17—C18	110.64 (15)
C11—C10—H10B	111.4	C17—C18—H18A	109.5
H10A—C10—H10B	109.3	C17—C18—H18B	109.5
C10—C11—H11A	109.5	H18A—C18—H18B	109.5
C10—C11—H11B	109.5	C17—C18—H18C	109.5
H11A—C11—H11B	109.5	H18A—C18—H18C	109.5
C10—C11—H11C	109.5	H18B—C18—H18C	109.5

D—H···A	D—H	H···A	D···A	D—H···A
N1—H1···O4i	0.86	2.30	3.074 (2)	149.

Table 1

Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N1—H1⋯O4i	0.86	2.30	3.074 (2)	149

Symmetry code: (i) .