Literature DB >> 22198578

Unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease: a favorable endogenous response.

Ramesh Kumar1, Archana Rastogi, J S Maras, Shiv Kumar Sarin.   

Abstract

The clinical significance of increased frequency of unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease (NAFLD) is unknown. Serum bilirubin is an endogenous anti-oxidant, and oxidative stress plays an important role in the pathogenesis of NAFLD. In this study, we have documented 25.4% prevalence of unconjugated hyperbilirubinemia in 204 consecutive NAFLD patients. These patients had a significantly less severe liver disease on histopathology and/or fibroScan which may be attributed to anti-oxidant effect of bilirubin.
Copyright © 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 22198578     DOI： 10.1016/j.clinbiochem.2011.11.017

Source DB:  PubMed          Journal:  Clin Biochem        ISSN： 0009-9120            Impact factor:   3.281


  15 in total

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Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2018-03-01       Impact factor: 4.052

Review 3.  Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications.

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Journal:  Pharmacol Ther       Date:  2021-09-06       Impact factor: 12.310

4.  Does bilirubin prevent hepatic steatosis through activation of the PPARα nuclear receptor?

Authors:  Terry D Hinds; Samuel O Adeosun; Abdulhadi A Alamodi; David E Stec
Journal:  Med Hypotheses       Date:  2016-08-31       Impact factor: 1.538

5.  Loss of biliverdin reductase-A promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells.

Authors:  Samuel O Adeosun; Darren M Gordon; Mary Frances Weeks; Kyle H Moore; John E Hall; Terry D Hinds; David E Stec
Journal:  Am J Physiol Renal Physiol       Date:  2018-04-04

6.  Hepatoprotective effect of calculus bovis sativus on nonalcoholic fatty liver disease in mice by inhibiting oxidative stress and apoptosis of hepatocytes.

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Journal:  Drug Des Devel Ther       Date:  2017-12-05       Impact factor: 4.162

7.  Molecular Interactions between NAFLD and Xenobiotic Metabolism.

Authors:  Adviti Naik; Aleš Belič; Ulrich M Zanger; Damjana Rozman
Journal:  Front Genet       Date:  2013-01-22       Impact factor: 4.599

8.  Elevated serum bilirubin levels are inversely associated with nonalcoholic fatty liver disease.

Authors:  Byoung Kuk Jang
Journal:  Clin Mol Hepatol       Date:  2012-12-21

9.  Serum bilirubin levels are inversely associated with nonalcoholic fatty liver disease.

Authors:  Min-Sun Kwak; Donghee Kim; Goh Eun Chung; Seung Joo Kang; Min Jung Park; Yoon Jun Kim; Jung-Hwan Yoon; Hyo-Suk Lee
Journal:  Clin Mol Hepatol       Date:  2012-12-21

10.  The Relationship between Serum Bilirubin and Elevated Fibrotic Indices among HBV Carriers: A Cross-Sectional Study of a Chinese Population.

Authors:  Min Du; Shanshan Zhang; Lin Xiao; Yanyan Xu; Peiyi Liu; Yuhan Tang; Sheng Wei; Mingyou Xing; Xiaoping Miao; Ping Yao
Journal:  Int J Mol Sci       Date:  2016-12-09       Impact factor: 5.923
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