Literature DB >> 22198199

The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast.

Thibaud T Renault1, Xavier Grandier-Vazeille, Hubert Arokium, Gisèle Velours, Nadine Camougrand, Muriel Priault, Oscar Teijido, Laurent M Dejean, Stéphen Manon.   

Abstract

The role of the mitochondrial protein receptor Tom22p in the interaction of pro-apoptotic protein Bax with yeast mitochondria was investigated. Co-immunoprecipitation assays showed that human Bax interacted with different TOM subunits, including Tom22p. Expression of the cytosolic receptor domain of human Tom22 increased Bax mitochondrial localization, but decreased the proportion of active Bax. BN-PAGE showed that the cytosolic domain of Tom22 interfered with the oligomerization of Bax. These data suggest that the interaction with the cytosolic domain of Tom22 helps Bax to acquire a conformation able to interact with the outer mitochondrial membrane.
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 22198199     DOI： 10.1016/j.febslet.2011.12.003

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Untangling the Roles of Anti-Apoptosis in Regulating Programmed Cell Death using Humanized Yeast Cells.

Authors:  Caitlin Clapp; Liam Portt; Chamel Khoury; Sara Sheibani; Rawan Eid; Matthew Greenwood; Hojatollah Vali; Craig A Mandato; Michael T Greenwood
Journal:  Front Oncol       Date:  2012-06-13       Impact factor: 6.244

Review 2.  Yeast as a tool for studying proteins of the Bcl-2 family.

Authors:  Peter Polčic; Petra Jaká; Marek Mentel
Journal:  Microb Cell       Date:  2015-03-02

Review 3.  Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death.

Authors:  Lisenn Lalier; François Vallette; Stéphen Manon
Journal:  Biomolecules       Date:  2022-01-19

Review 4.  Yeast as a tool to decipher the molecular mechanisms underlying the functions of Bcl-2 family.

Authors:  Stéphen Manon
Journal:  Explor Target Antitumor Ther       Date:  2022-04-02

Review 5.  A Biochemical and Structural Understanding of TOM Complex Interactions and Implications for Human Health and Disease.

Authors:  Ashley S Pitt; Susan K Buchanan
Journal:  Cells       Date:  2021-05-11       Impact factor: 6.600

6.  ER stress-mediated apoptosis induced by celastrol in cancer cells and important role of glycogen synthase kinase-3β in the signal network.

Authors:  L Feng; D Zhang; C Fan; C Ma; W Yang; Y Meng; W Wu; S Guan; B Jiang; M Yang; X Liu; D Guo
Journal:  Cell Death Dis       Date:  2013-07-11       Impact factor: 8.469

7.  IMB-6G, a novel N-substituted sophoridinic acid derivative, induces endoplasmic reticulum stress-mediated apoptosis via activation of IRE1α and PERK signaling.

Authors:  Na Zhang; Chongwen Bi; Lu Liu; Yueying Dou; Sheng Tang; Weiqiang Pang; Hongbin Deng; Danqing Song
Journal:  Oncotarget       Date:  2016-04-26
  7 in total

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