Literature DB >> 2219722

The complete DNA sequence of vaccinia virus.

S J Goebel1, G P Johnson, M E Perkus, S W Davis, J P Winslow, E Paoletti.   

Abstract

The complete DNA sequence of the genome of vaccinia virus has been determined. The genome consisted of 191,636 bp with a base composition of 66.6% A + T. We have identified 198 "major" protein-coding regions and 65 overlapping "minor" regions, for a total of 263 potential genes. Genes encoded by the virus were located by examination of DNA sequence characteristics and compared with existing vaccinia virus mapping analyses, sequence data, and transcription data. These genes were found to be compactly organized along the genome with relatively few regions of noncoding sequences. Whereas several similarities to proteins of known function were discerned, the function of the majority of proteins encoded by these open reading frames is as yet undetermined.

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Year:  1990        PMID： 2219722     DOI： 10.1016/0042-6822(90)90294-2

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  315 in total

1.  Conserved surface-exposed K/R-X-K/R motifs and net positive charge on poxvirus complement control proteins serve as putative heparin binding sites and contribute to inhibition of molecular interactions with human endothelial cells: a novel mechanism for evasion of host defense.

Authors:  S A Smith; N P Mullin; J Parkinson; S N Shchelkunov; A V Totmenin; V N Loparev; R Srisatjaluk; D N Reynolds; K L Keeling; D E Justus; P N Barlow; G J Kotwal
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

2.  Genome-wide analysis of vaccinia virus protein-protein interactions.

Authors:  S McCraith; T Holtzman; B Moss; S Fields
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-25       Impact factor: 11.205

3.  Clustered charge-to-alanine mutagenesis of the vaccinia virus H5 gene: isolation of a dominant, temperature-sensitive mutant with a profound defect in morphogenesis.

Authors:  J DeMasi; P Traktman
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

4.  Vaccinia virus F12L protein is required for actin tail formation, normal plaque size, and virulence.

Authors:  W H Zhang; D Wilcock; G L Smith
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

5.  A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.

Authors:  A Bowie; E Kiss-Toth; J A Symons; G L Smith; S K Dower; L A O'Neill
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-29       Impact factor: 11.205

6.  Common origin of four diverse families of large eukaryotic DNA viruses.

Authors:  L M Iyer; L Aravind; E V Koonin
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

7.  Role of vaccinia virus A20R protein in DNA replication: construction and characterization of temperature-sensitive mutants.

Authors:  K Ishii; B Moss
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

Review 8.  DNA glycosylases in the base excision repair of DNA.

Authors:  H E Krokan; R Standal; G Slupphaug
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

9.  Extensive gene gain associated with adaptive evolution of poxviruses.

Authors:  Aoife McLysaght; Pierre F Baldi; Brandon S Gaut
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-05       Impact factor: 11.205

10.  Vaccinia virus-mediated inhibition of type I interferon responses is a multifactorial process involving the soluble type I interferon receptor B18 and intracellular components.

Authors:  Zoe Waibler; Martina Anzaghe; Theresa Frenz; Astrid Schwantes; Christopher Pöhlmann; Holger Ludwig; Marcos Palomo-Otero; Antonio Alcamí; Gerd Sutter; Ulrich Kalinke
Journal:  J Virol       Date:  2008-12-10       Impact factor: 5.103
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