Literature DB >> 22197135

A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.

Guan-Jhong Huang1, M Vijaya Bhaskar Reddy, Ping-Chung Kuo, Chieh-Hung Huang, Hung-Cheng Shih, E-Jian Lee, Mei-Lin Yang, Yann-Lii Leu, Tian-Shung Wu.   

Abstract

In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.
Copyright © 2011 Elsevier Masson SAS. All rights reserved.

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Year:  2011        PMID： 22197135     DOI： 10.1016/j.ejmech.2011.12.008

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  9 in total

1.  Previous physical exercise alters the hepatic profile of oxidative-inflammatory status and limits the secondary brain damage induced by severe traumatic brain injury in rats.

Authors:  Mauro Robson Torres de Castro; Ana Paula de Oliveira Ferreira; Guilherme Lago Busanello; Luís Roberto Hart da Silva; Mauro Eduardo Porto da Silveira Junior; Fernando da Silva Fiorin; Gabriela Arrifano; Maria Elena Crespo-López; Rômulo Pillon Barcelos; María J Cuevas; Guilherme Bresciani; Javier González-Gallego; Michele Rechia Fighera; Luiz Fernando Freire Royes
Journal:  J Physiol       Date:  2017-07-30       Impact factor: 5.182

2.  Involvement of Heme Oxygenase-1 Participates in Anti-Inflammatory and Analgesic Effects of Aqueous Extract of Hibiscus taiwanensis.

Authors:  Shu-Ling Liu; Jeng-Shyan Deng; Chuan-Sung Chiu; Wen-Chi Hou; Shyh-Shyun Huang; Wang-Ching Lin; Jung-Chun Liao; Guan-Jhong Huang
Journal:  Evid Based Complement Alternat Med       Date:  2012-06-21       Impact factor: 2.629

3.  A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats.

Authors:  Mohammad Taghi Mansouri; Ali Asghar Hemmati; Bahareh Naghizadeh; Seyyed Ali Mard; Anahita Rezaie; Behnam Ghorbanzadeh
Journal:  Indian J Pharmacol       Date:  2015 May-Jun       Impact factor: 1.200

4.  Anti-inflammatory activity and mechanism of action of ethanolic leaf extract of Morinda lucida Benth.

Authors:  Frederick Ayertey; Ebenezer Ofori-Attah; Stephen Antwi; Michael Amoa-Bosompem; Georgina Djameh; Nathaniel Lartey Lartey; Mistuko Ohashi; Kwadwo Asamoah Kusi; Alfred Ampomah Appiah; Regina Appiah-Opong; Laud Kenneth Okine
Journal:  J Tradit Complement Med       Date:  2020-08-04

5.  Osthole Inhibits Expression of Genes Associated with Toll-like Receptor 2 Signaling Pathway in an Organotypic 3D Skin Model of Human Epidermis with Atopic Dermatitis.

Authors:  Natalia Karolina Kordulewska; Justyna Topa; Robert Stryiński; Beata Jarmołowska
Journal:  Cells       Date:  2021-12-28       Impact factor: 6.600

6.  Antioxidant, Antinociceptive, and Anti-Inflammatory Activities from Actinidia callosa var. callosa In Vitro and In Vivo.

Authors:  Jung-Chun Liao; Jeng-Shyan Deng; Ying-Chih Lin; Chao-Ying Lee; Min-Min Lee; Wen-Chi Hou; Shyh-Shyun Huang; Guan-Jhong Huang
Journal:  Evid Based Complement Alternat Med       Date:  2012-11-18       Impact factor: 2.629

7.  The prevention of 2,4-dinitrochlorobenzene-induced inflammation in atopic dermatitis-like skin lesions in BALB/c mice by Jawoongo.

Authors:  Jin Mo Ku; Se Hyang Hong; Soon Re Kim; Han-Seok Choi; Hyo In Kim; Dong Uk Kim; So Mi Oh; Hye Sook Seo; Tai Young Kim; Yong Cheol Shin; Chunhoo Cheon; Seong-Gyu Ko
Journal:  BMC Complement Altern Med       Date:  2018-07-13       Impact factor: 3.659

8.  Selective and Efficient Generation of ortho-Brominated para-Substituted Phenols in ACS-Grade Methanol.

Authors:  David Georgiev; Bartholomeus W H Saes; Heather J Johnston; Sarah K Boys; Alan Healy; Alison N Hulme
Journal:  Molecules       Date:  2016-01-13       Impact factor: 4.411

9.  Cordyceps cicadae Mycelia Ameliorate Cisplatin-Induced Acute Kidney Injury by Suppressing the TLR4/NF-κB/MAPK and Activating the HO-1/Nrf2 and Sirt-1/AMPK Pathways in Mice.

Authors:  Jeng-Shyan Deng; Wen-Ping Jiang; Chin-Chu Chen; Li-Ya Lee; Pei-Ying Li; Wen-Chin Huang; Jung-Chun Liao; Hung-Yi Chen; Shyh-Shyun Huang; Guan-Jhong Huang
Journal:  Oxid Med Cell Longev       Date:  2020-02-06       Impact factor: 6.543
  9 in total

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