Literature DB >> 22196121

A simple oxazolidine linker for solid-phase synthesis of peptide aldehydes.

Wu Kang1, Weiguo Wang, Xiaoxia Zhi, Bo Zhang, Ping Wei, Hongyan Xu.   

Abstract

A very simple and cheap linker has been used for solid-phase synthesis of peptide aldehydes. Protected amino acid aldehydes are immobilized on 2-Cl(trt) resin as oxazolidine formation via diethanolamine. After classical Fmoc SPPS, treatment of the resin with AcOH/DCM/H(2)O (8:1:1) affords peptide aldehydes in high yield and purity.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 22196121     DOI： 10.1016/j.bmcl.2011.11.081

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Solid phase synthesis of mitochondrial triphenylphosphonium-vitamin E metabolite using a lysine linker for reversal of oxidative stress.

Authors:  Mohanad Mossalam; Jamie Soto; Carol S Lim; E Dale Abel
Journal:  PLoS One       Date:  2013-01-14       Impact factor: 3.240

2.  Practical synthesis of peptide C-terminal aldehyde on a solid support.

Authors:  Hiroyuki Konno; Yoshihiro Sema; Manabu Ishii; Yasunao Hattori; Kazuto Nosaka; Kenichi Akaji
Journal:  Tetrahedron Lett       Date:  2013-06-28       Impact factor: 2.415
  2 in total

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