Literature DB >> 22194014

Diverse functions of ATP-dependent chromatin remodeling complexes in development and cancer.

Jiang I Wu1.   

Abstract

Mammalian SWI/SNF like Brg1/Brm associated factors (BAF) chromatin-remodeling complexes are able to use energy derived from adenosine triphosphate (ATP) hydrolysis to change chromatin structures and regulate nuclear processes such as transcription. BAF complexes contain multiple subunits and the diverse subunit compositions provide functional specificities to BAF complexes. In this review, we summarize the functions of BAF subunits during mammalian development and in progression of various cancers. The mechanisms underlying the functional diversity and specificities of BAF complexes will be discussed.

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Year:  2012        PMID： 22194014     DOI： 10.1093/abbs/gmr099

Source DB:  PubMed          Journal:  Acta Biochim Biophys Sin (Shanghai)        ISSN： 1672-9145            Impact factor:   3.848


  50 in total

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5.  The conserved PBAF nucleosome-remodeling complex mediates the response to stress in Caenorhabditis elegans.

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6.  Mutations in the BAF-Complex Subunit DPF2 Are Associated with Coffin-Siris Syndrome.

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7.  Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development.

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8.  Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response.

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9.  Aberrant BAF57 signaling facilitates prometastatic phenotypes.

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10.  Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.

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