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Literature DB >> 22193776

Xenopus paraxial protocadherin inhibits Wnt/β-catenin signalling via casein kinase 2β.

Anja Kietzmann¹, Yingqun Wang, Dominik Weber, Herbert Steinbeisser.

Abstract

Xenopus paraxial protocadherin (PAPC) regulates cadherin-mediated cell adhesion and promotes the planar cell polarity (PCP) pathway. Here we report that PAPC functions in the Xenopus gastrula as an inhibitor of the Wnt/β-catenin pathway. The intracellular domain of PAPC interacts with casein kinase 2 beta (CK2β), which is part of the CK2 holoenzyme. The CK2α/β complex stimulates Wnt/β-catenin signalling, and the physical interaction of CK2β with PAPC antagonizes this activity. By this mechanism, PAPC restricts the expression of Wnt target genes during gastrulation. These experiments identify a novel function of protocadherins as regulators of the Wnt pathway.

Entities: Gene Species

Mesh：

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Year: 2012 PMID： 22193776 PMCID： PMC3271334 DOI： 10.1038/embor.2011.240

Source DB: PubMed Journal: EMBO Rep ISSN： 1469-221X Impact factor: 8.807

28 in total

1. Protein kinase CK2 is required for dorsal axis formation in Xenopus embryos.

Authors: Isabel Dominguez; Junko Mizuno; Hao Wu; Diane H Song; Karen Symes; David C Seldin
Journal: Dev Biol Date: 2004-10-01 Impact factor: 3.582

Review 2. Rethinking WNT signaling.

Authors: Nicholas S Tolwinski; Eric Wieschaus
Journal: Trends Genet Date: 2004-04 Impact factor: 11.639

3. Casein kinase 2 associates with and phosphorylates dishevelled.

Authors: K Willert; M Brink; A Wodarz; H Varmus; R Nusse
Journal: EMBO J Date: 1997-06-02 Impact factor: 11.598

Review 4. Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation.

Authors: J E Allende; C C Allende
Journal: FASEB J Date: 1995-03 Impact factor: 5.191

5. Combinatorial signalling by Xwnt-11 and Xnr3 in the organizer epithelium.

Authors: A Glinka; H Delius; C Blumenstock; C Niehrs
Journal: Mech Dev Date: 1996-12 Impact factor: 1.882

6. Xenopus paraxial protocadherin has signaling functions and is involved in tissue separation.

Authors: Araceli Medina; Rajeeb K Swain; Klaus-Michael Kuerner; Herbert Steinbeisser
Journal: EMBO J Date: 2004-07-22 Impact factor: 11.598

Review 7. Dorsal-ventral patterning and neural induction in Xenopus embryos.

Authors: Edward M De Robertis; Hiroki Kuroda
Journal: Annu Rev Cell Dev Biol Date: 2004 Impact factor: 13.827

8. A nodal-related gene defines a physical and functional domain within the Spemann organizer.

Authors: W C Smith; R McKendry; S Ribisi; R M Harland
Journal: Cell Date: 1995-07-14 Impact factor: 41.582

9. Induction of epidermis and inhibition of neural fate by Bmp-4.

Authors: P A Wilson; A Hemmati-Brivanlou
Journal: Nature Date: 1995-07-27 Impact factor: 49.962

10. Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development.

Authors: M A Torres; J A Yang-Snyder; S M Purcell; A A DeMarais; L L McGrew; R T Moon
Journal: J Cell Biol Date: 1996-06 Impact factor: 10.539

8 in total

Xenopus paraxial protocadherin inhibits Wnt/β-catenin signalling via casein kinase 2β.

1. Protein kinase CK2 is required for dorsal axis formation in Xenopus embryos.

Review 2. Rethinking WNT signaling.

3. Casein kinase 2 associates with and phosphorylates dishevelled.

Review 4. Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation.

5. Combinatorial signalling by Xwnt-11 and Xnr3 in the organizer epithelium.

6. Xenopus paraxial protocadherin has signaling functions and is involved in tissue separation.

Review 7. Dorsal-ventral patterning and neural induction in Xenopus embryos.

8. A nodal-related gene defines a physical and functional domain within the Spemann organizer.

9. Induction of epidermis and inhibition of neural fate by Bmp-4.

10. Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development.

Review 1. Regulation of Wnt signaling by protocadherins.

Review 2. Nuclear signaling from cadherin adhesion complexes.

3. Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling.

Review 4. Aberrant expression and functions of protocadherins in human malignant tumors.

5. GSK3 and Polo-like kinase regulate ADAM13 function during cranial neural crest cell migration.

6. The γ-Protocadherin-C3 isoform inhibits canonical Wnt signalling by binding to and stabilizing Axin1 at the membrane.

7. Functions of block of proliferation 1 during anterior development in Xenopus laevis.

Review 8. Ephrin-Eph signaling in embryonic tissue separation.