Tracey L Bonfield1, Kristie R Ross. 1. Division of Pediatrics, Departments of Pulmonary and Allergy, Case Western Reserve University, Cleveland, Ohio 44106-4948, USA. Tracey.Bonfield@case.edu
Abstract
PURPOSE OF REVIEW: Asthma is a chronic pulmonary inflammatory disease affecting all races, children and adults. The causative or intrinsic development of asthma is diverse, ranging from episodic exposure to environmental insults to physical induction in exercise. RECENT FINDINGS: Asthma uniquely manifests in affected individuals as episodes of airway hyper-reactivity, chronic airway obstruction, and inflammation. The diversity in asthmatic phenotypes and the mechanisms that lead to initiation and perpetuation of the lung disease continue to make asthma a challenge to treat, classify, and manage therapeutically. SUMMARY: This review will focus on the newest of mechanistic insights into asthma development, therapeutic innovations, and clinical applications.
PURPOSE OF REVIEW: Asthma is a chronic pulmonary inflammatory disease affecting all races, children and adults. The causative or intrinsic development of asthma is diverse, ranging from episodic exposure to environmental insults to physical induction in exercise. RECENT FINDINGS:Asthma uniquely manifests in affected individuals as episodes of airway hyper-reactivity, chronic airway obstruction, and inflammation. The diversity in asthmatic phenotypes and the mechanisms that lead to initiation and perpetuation of the lung disease continue to make asthma a challenge to treat, classify, and manage therapeutically. SUMMARY: This review will focus on the newest of mechanistic insights into asthma development, therapeutic innovations, and clinical applications.
Authors: Cecilia K Andersson; Jua Iwasaki; James Cook; Polly Robinson; Prasad Nagakumar; Sofia Mogren; Louise Fleming; Andrew Bush; Sejal Saglani; Clare M Lloyd Journal: Allergy Date: 2020-07-15 Impact factor: 14.710
Authors: Therese M Murphy; Chloe C Y Wong; Louise Arseneault; Joe Burrage; Ruby Macdonald; Eilis Hannon; Helen L Fisher; Antony Ambler; Terrie E Moffitt; Avshalom Caspi; Jonathan Mill Journal: Clin Epigenetics Date: 2015-12-18 Impact factor: 6.551
Authors: Bert Rutten; Simon Young; Magdalena Rhedin; Marita Olsson; Nisha Kurian; Farhat Syed; Augusta Beech; Mark Fidock; Paul Newbold; Dave Singh; Adam Platt; Glen Hughes Journal: PLoS One Date: 2021-02-10 Impact factor: 3.240
Authors: Daniel W Belsky; Malcolm R Sears; Robert J Hancox; Honalee Harrington; Renate Houts; Terrie E Moffitt; Karen Sugden; Benjamin Williams; Richie Poulton; Avshalom Caspi Journal: Lancet Respir Med Date: 2013-06-28 Impact factor: 30.700
Authors: Alexey V Polonikov; Vladimir P Ivanov; Alexey D Bogomazov; Maxim B Freidin; Thomas Illig; Maria A Solodilova Journal: Biomed Res Int Date: 2014-05-05 Impact factor: 3.411