PURPOSE OF REVIEW: To discuss the role of vitamin D in chronic rhinitis and chronic rhinosinusitis (CRS). RECENT FINDINGS: Vitamin D has been shown to have an immunomodulatory effect with a significant impact on immune function. Specifically, vitamin D regulates the mechanisms which suppress the inflammatory response and direct the differentiation fate of immune cells. Vitamin D has been shown to play an important role in asthma, and the concept of the unified airway model allows the extrapolation of vitamin D as a critical player in chronic rhinitis and rhinosinusitis. SUMMARY: Recent findings on the function of vitamin D may explain aspects of the pathophysiology of chronic rhinitis and CRS, and may help direct future treatment of these diseases.
PURPOSE OF REVIEW: To discuss the role of vitamin D in chronic rhinitis and chronic rhinosinusitis (CRS). RECENT FINDINGS:Vitamin D has been shown to have an immunomodulatory effect with a significant impact on immune function. Specifically, vitamin D regulates the mechanisms which suppress the inflammatory response and direct the differentiation fate of immune cells. Vitamin D has been shown to play an important role in asthma, and the concept of the unified airway model allows the extrapolation of vitamin D as a critical player in chronic rhinitis and rhinosinusitis. SUMMARY: Recent findings on the function of vitamin D may explain aspects of the pathophysiology of chronic rhinitis and CRS, and may help direct future treatment of these diseases.
Authors: David E McCarty; Aronkumar Reddy; Quinton Keigley; Paul Y Kim; Andrew A Marino Journal: J Clin Sleep Med Date: 2012-12-15 Impact factor: 4.062
Authors: Umesh Goswami; Kristine E Ensrud; Misti L Paudel; Susan Redline; Eva S Schernhammer; James M Shikany; Katie L Stone; Ken M Kunisaki Journal: Ann Am Thorac Soc Date: 2016-05
Authors: Edwin Hoe; Jordan Nathanielsz; Zheng Quan Toh; Leena Spry; Rachel Marimla; Anne Balloch; Kim Mulholland; Paul V Licciardi Journal: Nutrients Date: 2016-12-12 Impact factor: 5.717