BACKGROUND: The reasons for the long-term complete or partial loss of islet graft function are unknown, but there are obviously other reasons than just pure allogeneic graft rejection. Earlier studies have shown that deposition of islet amyloid polypeptide amyloid in transplanted islets may indicate a mechanism for loss of β cells. MATERIALS AND METHODS: Sections from liver material from four deceased islet-bearing recipients have been scrutinized for the presence of amyloid. Clinical data and certain aspects of the islet graft pathology of these patients have been published previously. RESULT: With this extended histological analysis, we demonstrate the occurrence of amyloid deposits in islets transplanted into the liver in three of four patients with type 1 diabetes. CONCLUSION: The finding adds evidence to the assumption that aggregation of islet amyloid polypeptide might be an important cause of progressing β-cell dysfunction in clinically transplanted islets.
BACKGROUND: The reasons for the long-term complete or partial loss of islet graft function are unknown, but there are obviously other reasons than just pure allogeneic graft rejection. Earlier studies have shown that deposition of islet amyloid polypeptide amyloid in transplanted islets may indicate a mechanism for loss of β cells. MATERIALS AND METHODS: Sections from liver material from four deceased islet-bearing recipients have been scrutinized for the presence of amyloid. Clinical data and certain aspects of the islet graft pathology of these patients have been published previously. RESULT: With this extended histological analysis, we demonstrate the occurrence of amyloid deposits in islets transplanted into the liver in three of four patients with type 1 diabetes. CONCLUSION: The finding adds evidence to the assumption that aggregation of islet amyloid polypeptide might be an important cause of progressing β-cell dysfunction in clinically transplanted islets.
Authors: J Janson; W C Soeller; P C Roche; R T Nelson; A J Torchia; D K Kreutter; P C Butler Journal: Proc Natl Acad Sci U S A Date: 1996-07-09 Impact factor: 11.205
Authors: A M James Shapiro; Camillo Ricordi; Bernhard J Hering; Hugh Auchincloss; Robert Lindblad; R Paul Robertson; Antonio Secchi; Mathias D Brendel; Thierry Berney; Daniel C Brennan; Enrico Cagliero; Rodolfo Alejandro; Edmond A Ryan; Barbara DiMercurio; Philippe Morel; Kenneth S Polonsky; Jo-Anna Reems; Reinhard G Bretzel; Federico Bertuzzi; Tatiana Froud; Raja Kandaswamy; David E R Sutherland; George Eisenbarth; Miriam Segal; Jutta Preiksaitis; Gregory S Korbutt; Franca B Barton; Lisa Viviano; Vicki Seyfert-Margolis; Jeffrey Bluestone; Jonathan R T Lakey Journal: N Engl J Med Date: 2006-09-28 Impact factor: 91.245
Authors: K J Potter; A Abedini; P Marek; A M Klimek; S Butterworth; M Driscoll; R Baker; M R Nilsson; G L Warnock; J Oberholzer; S Bertera; M Trucco; G S Korbutt; P E Fraser; D P Raleigh; C B Verchere Journal: Proc Natl Acad Sci U S A Date: 2010-02-16 Impact factor: 11.205
Authors: Daniel T Meier; Ling-Hsien Tu; Sakeneh Zraika; Meghan F Hogan; Andrew T Templin; Rebecca L Hull; Daniel P Raleigh; Steven E Kahn Journal: J Biol Chem Date: 2015-10-19 Impact factor: 5.157
Authors: Melena D Bellin; Andres Gelrud; Guillermo Arreaza-Rubin; Ty B Dunn; Abhinav Humar; Katherine A Morgan; Bashoo Naziruddin; Cristiana Rastellini; Michael R Rickels; Sarah J Schwarzenberg; Dana K Andersen Journal: Pancreas Date: 2014-11 Impact factor: 3.327
Authors: Melena D Bellin; Andres Gelrud; Guillermo Arreaza-Rubin; Ty B Dunn; Abhinav Humar; Katherine A Morgan; Bashoo Naziruddin; Cristiana Rastellini; Michael R Rickels; Sarah J Schwarzenberg; Dana K Andersen Journal: Ann Surg Date: 2015-01 Impact factor: 12.969
Authors: J Udayasankar; S Zraika; K Aston-Mourney; S L Subramanian; B M Brooks-Worrell; G J Taborsky; R L Hull Journal: Transplant Proc Date: 2012-09-25 Impact factor: 1.066
Authors: Y J Park; Z Ao; T J Kieffer; H Chen; N Safikhan; D M Thompson; M Meloche; G L Warnock; L Marzban Journal: Diabetologia Date: 2012-12-23 Impact factor: 10.122
Authors: Andrew T Templin; Daniel T Meier; Joshua R Willard; Tami Wolden-Hanson; Kelly Conway; Yin-Guo Lin; Patrick J Gillespie; Krister B Bokvist; Giorgio Attardo; Steven E Kahn; Donalyn Scheuner; Rebecca L Hull Journal: Diabetologia Date: 2018-07-25 Impact factor: 10.122