BACKGROUND:Picosulfate, magnesium oxide, and citric acid solution is a small-volume agent for colon cleansing before colonoscopy that is extremely well tolerated by patients, safe, and efficacious. Studies of other cleansing agents have suggested that split-dose regimens may further enhance efficacy. OBJECTIVE: To examine whether split-dosing of picosulfate, magnesium oxide, and citric acid solution increases bowel cleansing efficacy while maintaining tolerability and safety. DESIGN: Prospective, randomized, single-blinded, controlled trial. SETTING:Outpatient tertiary care center. PATIENTS: A total of 236 patients underwent colonoscopy (mean age 56 years, 53.8% female). INTERVENTIONS: Patients in the traditional arm (n = 123) consumed 1 sachet of solution at 5:00 pm and 10:00 pm the night before the colonoscopy. Patients in the split-dose arm (n = 127) consumed 1 sachet at 7:00 pm the night before and another sachet 4 hours before their colonoscopy appointment. MAIN OUTCOME MEASUREMENTS: Ottawa Bowel Preparation Scale (OBPS) score, Aronchick score, safety, tolerability. RESULTS: The 113 and 109 patients in the split-dose and traditional arms, respectively, had OBPS scores for analysis. Overall, the OBPS scores in the split-dose group were significantly improved compared with the traditional dose group (4.05 vs 5.51, P < .001). This was mostly attributed to improvements in right-sided colon cleansing (1.22 in split-dose vs 2.14 in traditional arm, P < .001). Both regimens were well tolerated by patients, and no safety issues were identified. LIMITATIONS: This was a single-center study. Disturbances in sleep related to the preparation were not assessed. CONCLUSIONS: The split-dose regimen of picosulfate, magnesium oxide, and citric acid solution is superior to the traditional dosing regimen for colon cleansing before colonoscopy. ( CLINICAL TRIAL REGISTRATION NUMBER: NCT00885274.).
RCT Entities:
BACKGROUND:Picosulfate, magnesium oxide, and citric acid solution is a small-volume agent for colon cleansing before colonoscopy that is extremely well tolerated by patients, safe, and efficacious. Studies of other cleansing agents have suggested that split-dose regimens may further enhance efficacy. OBJECTIVE: To examine whether split-dosing of picosulfate, magnesium oxide, and citric acid solution increases bowel cleansing efficacy while maintaining tolerability and safety. DESIGN: Prospective, randomized, single-blinded, controlled trial. SETTING:Outpatient tertiary care center. PATIENTS: A total of 236 patients underwent colonoscopy (mean age 56 years, 53.8% female). INTERVENTIONS:Patients in the traditional arm (n = 123) consumed 1 sachet of solution at 5:00 pm and 10:00 pm the night before the colonoscopy. Patients in the split-dose arm (n = 127) consumed 1 sachet at 7:00 pm the night before and another sachet 4 hours before their colonoscopy appointment. MAIN OUTCOME MEASUREMENTS: Ottawa Bowel Preparation Scale (OBPS) score, Aronchick score, safety, tolerability. RESULTS: The 113 and 109 patients in the split-dose and traditional arms, respectively, had OBPS scores for analysis. Overall, the OBPS scores in the split-dose group were significantly improved compared with the traditional dose group (4.05 vs 5.51, P < .001). This was mostly attributed to improvements in right-sided colon cleansing (1.22 in split-dose vs 2.14 in traditional arm, P < .001). Both regimens were well tolerated by patients, and no safety issues were identified. LIMITATIONS: This was a single-center study. Disturbances in sleep related to the preparation were not assessed. CONCLUSIONS: The split-dose regimen of picosulfate, magnesium oxide, and citric acid solution is superior to the traditional dosing regimen for colon cleansing before colonoscopy. ( CLINICAL TRIAL REGISTRATION NUMBER: NCT00885274.).
Authors: Ki Hwan Song; Wu Seok Suh; Jin Sik Jeong; Dong Sik Kim; Sang Woo Kim; Dong Min Kwak; Jong Seong Hwang; Hyun Jin Kim; Man Woo Park; Min Chul Shim; Ja-Il Koo; Jae Hwang Kim; Dae Ho Shon Journal: Ann Coloproctol Date: 2014-10-28
Authors: Miguel Muñoz-Navas; José Luis Calleja; Guillermo Payeras; Antonio José Hervás; Luis Esteban Abreu; Víctor Orive; Pedro L Menchén; José María Bordas; José Ramón Armengol; Cristina Carretero; Vicente Pons Beltrán; Inmaculada Alonso-Abreu; Román Manteca; Adolfo Parra-Blanco; Fernando Carballo; Juan Manuel Herrerías; Carlos Badiola Journal: Int J Colorectal Dis Date: 2015-07-16 Impact factor: 2.571
Authors: Ilvy van Lieshout; Isabelle D Munsterman; Anne M Eskes; Jolanda M Maaskant; René van der Hulst Journal: United European Gastroenterol J Date: 2016-12-12 Impact factor: 4.623