Literature DB >> 22192308

A bifunctional dimethylsulfoxide substitute enhances the aqueous solubility of small organic molecules.

Melissa M Sprachman1, Peter Wipf.   

Abstract

An oxetane-substituted sulfoxide has demonstrated potential as a dimethylsulfoxide substitute for enhancing the dissolution of organic compounds with poor aqueous solubilities. This sulfoxide may find utility in applications of library storage and biological assays. For the model compounds studied, significant solubility enhancements were observed using the sulfoxide as a cosolvent in aqueous media. Brine shrimp, breast cancer (MDA-MB-231), and liver cell line (HepG2) toxicity data for the new additive are also presented, in addition to comparative IC(50) values for a series of PKD1 inhibitors.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 22192308      PMCID： PMC3374385          DOI： 10.1089/adt.2011.0421

Source DB:  PubMed          Journal:  Assay Drug Dev Technol        ISSN： 1540-658X            Impact factor:   1.738


  24 in total

1.  Use of 1-methyl-pyrrolidone as a solubilizing agent for determining the uptake of poorly soluble drugs.

Authors:  A S Uch; U Hesse; J B Dressman
Journal:  Pharm Res       Date:  1999-06       Impact factor: 4.200

2.  The effect of room-temperature storage on the stability of compounds in DMSO.

Authors:  Barbara A Kozikowski; Thomas M Burt; Debra A Tirey; Lisa E Williams; Barbara R Kuzmak; David T Stanton; Kenneth L Morand; Sandra L Nelson
Journal:  J Biomol Screen       Date:  2003-04

Review 3.  Solubilizing excipients in oral and injectable formulations.

Authors:  Robert G Strickley
Journal:  Pharm Res       Date:  2004-02       Impact factor: 4.200

4.  [Cancerogenic alkylating substances. 3. Alkyl-halogenides, -sulfates, -sulfonates and strained heterocyclic compounds].

Authors:  H Druckrey; H Kruse; R Preussmann; S Ivankovic; C Landschütz
Journal:  Z Krebsforsch       Date:  1970

5.  Brine shrimp: a convenient general bioassay for active plant constituents.

Authors:  B N Meyer; N R Ferrigni; J E Putnam; L B Jacobsen; D E Nichols; J L McLaughlin
Journal:  Planta Med       Date:  1982-05       Impact factor: 3.352

6.  A computational study to elucidate the extraordinary reactivity of three-membered heterocycles in nucleophilic substitution reactions.

Authors:  Harold D Banks
Journal:  J Org Chem       Date:  2003-04-04       Impact factor: 4.354

7.  Poly-L-methionine sulfoxide: a biologically inert analogue of dimethyl sulfoxide with solubilizing potency.

Authors:  J Pitha; L Szente; J Greenberg
Journal:  J Pharm Sci       Date:  1983-06       Impact factor: 3.534

8.  Nonracemizable isocyanoacetates for multicomponent reactions.

Authors:  Alexander G Zhdanko; Valentine G Nenajdenko
Journal:  J Org Chem       Date:  2009-01-16       Impact factor: 4.354

9.  Solubility improvement of drugs using N-methyl pyrrolidone.

Authors:  Ritesh Sanghvi; Ryuichi Narazaki; Stephen G Machatha; Samuel H Yalkowsky
Journal:  AAPS PharmSciTech       Date:  2008-02-20       Impact factor: 3.246

10.  Further studies on the carcinogenic and growth-inhibitory activity of lactones and related substances.

Authors:  F DICKENS; H E JONES
Journal:  Br J Cancer       Date:  1963-03       Impact factor: 7.640
View more
  7 in total

1.  Amelioration of radiation-induced pulmonary fibrosis by a water-soluble bifunctional sulfoxide radiation mitigator (MMS350).

Authors:  Ronny Kalash; Michael W Epperly; Julie Goff; Tracy Dixon; Melissa M Sprachman; Xichen Zhang; Donna Shields; Shaonan Cao; Darcy Franicola; Peter Wipf; Hebist Berhane; Hong Wang; Jeremiah Au; Joel S Greenberger
Journal:  Radiat Res       Date:  2013-10-14       Impact factor: 2.841

2.  An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility.

Authors:  Erin M Skoda; Joshua R Sacher; Mustafa Z Kazancioglu; Jaideep Saha; Peter Wipf
Journal:  ACS Med Chem Lett       Date:  2014-06-27       Impact factor: 4.345

3.  Continuous One Year Oral Administration of the Radiation Mitigator, MMS350, after Total-Body Irradiation, Restores Bone Marrow Stromal Cell Proliferative Capacity and Reduces Senescence in Fanconi Anemia (Fanca-/-) Mice.

Authors:  Aranee Sivananthan; Donna Shields; Renee Fisher; Wen Hou; Xichen Zhang; Darcy Franicola; Michael W Epperly; Peter Wipf; Joel S Greenberger
Journal:  Radiat Res       Date:  2018-11-30       Impact factor: 2.841

4.  Oxetanyl Sulfoxide MMS-350 Ameliorates Pulmonary Fibrosis In Vitro, In Vivo, and Ex Vivo.

Authors:  Logan Mlakar; Jessica Lane; Takahisa Takihara; Chaemin Lim; Melissa M Sprachman; Kayla R Lloyd; Peter Wipf; Carol Feghali-Bostwick
Journal:  ACS Med Chem Lett       Date:  2020-09-10       Impact factor: 4.345

5.  Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells.

Authors:  Julie P Goff; Donna S Shields; Hong Wang; Erin M Skoda; Melissa M Sprachman; Peter Wipf; Venkata Krishna Garapati; Jeffrey Atkinson; Barry London; John S Lazo; Valerian Kagan; Michael W Epperly; Joel S Greenberger
Journal:  Exp Hematol       Date:  2013-08-07       Impact factor: 3.084

6.  A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis.

Authors:  Tanja Krainz; Michael M Gaschler; Chaemin Lim; Joshua R Sacher; Brent R Stockwell; Peter Wipf
Journal:  ACS Cent Sci       Date:  2016-09-07       Impact factor: 14.553

7.  Evaluation of anthoxanthins and their actions on digestive enzyme inhibition when used independently and in combination.

Authors:  Yong Qin Koh; Yu Ang Desmond Sin; Hengyang Justin Rong; Teng Hui Sean Chua; Si-Han Sherman Ho; Han Kiat Ho
Journal:  Heliyon       Date:  2022-08-08
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.