BACKGROUND: It is still controversial whether carotid plaque is associated with cardiovascular events in patients with coronary artery disease (CAD). The aim of the present study is to evaluate the impact of carotid plaque on long term clinical outcomes especially in patients with CAD. METHODS: The study population consisted of 1390 consecutive patients with angiographically proven CAD. All subjects underwent carotid scanning 1 day before or after coronary angiogram and were followed up for major adverse cardiovascular events (MACE; death, myocardial infarction, stroke, revascularization, restenosis and hospitalization for heart failure) during a mean of 54.2 ± 23.9 months. RESULTS: Patients with carotid plaque (n=433) were older, had higher prevalence of cardiovascular risk factors and acute coronary syndrome (34.2% vs. 24.6%, p<0.001) than those without carotid plaque (n=957). On univariate analysis, the presence of carotid plaque was a predictor of cardiac death, hard MACE (death, myocardial infarction and stroke) and total MACE, whereas carotid intima-media thickness (CIMT) was a predictor of total MACE. Multivariate analysis revealed that carotid plaque was associated with cardiac death (HR 6.99, 95% CI 1.88-25.95, p=0.004), hard MACE (HR 1.89, 95% CI 1.18-3.04, p=0.008) and total MACE (HR 1.47, 95% CI 1.13-1.90, p=0.004), whereas CIMT was associated only with total MACE (HR 1.39, 95% CI 1.06-1.81, p=0.017). CONCLUSIONS: Carotid plaque is a strong predictor of future cardiac death and MACE in patients with CAD. This study suggests that carotid plaque has additional value for secondary prevention and more important prognostic factor than CIMT in patients with CAD.
BACKGROUND: It is still controversial whether carotid plaque is associated with cardiovascular events in patients with coronary artery disease (CAD). The aim of the present study is to evaluate the impact of carotid plaque on long term clinical outcomes especially in patients with CAD. METHODS: The study population consisted of 1390 consecutive patients with angiographically proven CAD. All subjects underwent carotid scanning 1 day before or after coronary angiogram and were followed up for major adverse cardiovascular events (MACE; death, myocardial infarction, stroke, revascularization, restenosis and hospitalization for heart failure) during a mean of 54.2 ± 23.9 months. RESULTS:Patients with carotid plaque (n=433) were older, had higher prevalence of cardiovascular risk factors and acute coronary syndrome (34.2% vs. 24.6%, p<0.001) than those without carotid plaque (n=957). On univariate analysis, the presence of carotid plaque was a predictor of cardiac death, hard MACE (death, myocardial infarction and stroke) and total MACE, whereas carotid intima-media thickness (CIMT) was a predictor of total MACE. Multivariate analysis revealed that carotid plaque was associated with cardiac death (HR 6.99, 95% CI 1.88-25.95, p=0.004), hard MACE (HR 1.89, 95% CI 1.18-3.04, p=0.008) and total MACE (HR 1.47, 95% CI 1.13-1.90, p=0.004), whereas CIMT was associated only with total MACE (HR 1.39, 95% CI 1.06-1.81, p=0.017). CONCLUSIONS: Carotid plaque is a strong predictor of future cardiac death and MACE in patients with CAD. This study suggests that carotid plaque has additional value for secondary prevention and more important prognostic factor than CIMT in patients with CAD.
Authors: Ankush Jamthikar; Deep Gupta; Narendra N Khanna; Tadashi Araki; Luca Saba; Andrew Nicolaides; Aditya Sharma; Tomaz Omerzu; Harman S Suri; Ajay Gupta; Sophie Mavrogeni; Monika Turk; John R Laird; Athanasios Protogerou; Petros P Sfikakis; George D Kitas; Vijay Viswanathan; Gyan Pareek; Martin Miner; Jasjit S Suri Journal: Curr Atheroscler Rep Date: 2019-05-01 Impact factor: 5.113
Authors: Amer M Johri; Katherine A Lajkosz; Nicholas Grubic; Saadul Islam; Terry Y Li; Christopher S Simpson; Paul Ewart; Jasjit S Suri; Marie-France Hétu Journal: Int J Cardiovasc Imaging Date: 2021-01-27 Impact factor: 2.357
Authors: Dionicio A Galarza-Delgado; Jose R Azpiri-Lopez; Iris J Colunga-Pedraza; Jesus A Cardenas-de la Garza; Raymundo Vera-Pineda; Judith I Garcia-Colunga; Rosa I Arvizu-Rivera; Adrian Martinez-Moreno; Jesus Z Villarreal-Perez; Guillermo Elizondo-Riojas; Mario A Garza Elizondo Journal: Clin Rheumatol Date: 2016-05-25 Impact factor: 2.980
Authors: Ankush Jamthikar; Deep Gupta; Narendra N Khanna; Luca Saba; Tadashi Araki; Klaudija Viskovic; Harman S Suri; Ajay Gupta; Sophie Mavrogeni; Monika Turk; John R Laird; Gyan Pareek; Martin Miner; Petros P Sfikakis; Athanasios Protogerou; George D Kitas; Vijay Viswanathan; Andrew Nicolaides; Deepak L Bhatt; Jasjit S Suri Journal: Cardiovasc Diagn Ther Date: 2019-10
Authors: Hyung Bin Yuk; Hyun Woong Park; Ik Ju Jung; Wan Ho Kim; Ki-Hong Kim; Dong-Ju Yang; Yo Han Park; Yong Kyun Kim; In Geol Song; Jang-Ho Bae Journal: Korean Circ J Date: 2015-01-26 Impact factor: 3.243