| Literature DB >> 22190509 |
Jun-Feng He1, Yu-Mei Luo, Xin-Hong Wan, Deqian Jiang.
Abstract
microRNA-195(miR-195) is an important member of the micro-15/16/195/424/497 family, and which is activated in multiple diseases, such as cancers, heart failure, and schizophrenia. Mir-195 regulates a plethora of target proteins, which are involved in the cell cycle, apoptosis, proliferation. WEE1, CDK6, and Bcl-2 are confirmed target genes of miR-195 that are involved in miR-195-mediated cell-cycle and apoptosis effects. However, the mechanism of miR-195 action is not completely understood. This review summarizes recent the research progress regarding the roles of miR-195 in the cell cycle and in apoptosis.Entities:
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Year: 2011 PMID: 22190509 DOI: 10.1002/jbt.20396
Source DB: PubMed Journal: J Biochem Mol Toxicol ISSN: 1095-6670 Impact factor: 3.642