INTRODUCTION: Strength measures with reduced variability and higher sensitivity could improve efficiency in clinical trials of amyotrophic lateral sclerosis (ALS). The Accurate Test of Limb Isometric Strength (ATLIS) was developed to precisely and conveniently measure force in 12 muscle groups. In this study we evaluate the reliability and validity of the ATLIS testing protocol. METHODS: Twenty healthy adults and 10 patients with ALS were tested twice by the same or by different evaluators to determine test-retest and interrater reliability. Twenty healthy adults were examined using ATLIS and a well-validated strength testing protocol (TQNE) to assess criterion-based validity. RESULTS: Mean absolute variation between tests was 8.6%, and intraclass correlation coefficients for each muscle group were high (range 0.82-0.99). The Pearson correlation coefficient of mean ATLIS and TQNE scores was 0.90. A subject survey demonstrated high user acceptance of ATLIS. CONCLUSIONS: ATLIS is convenient for patients and evaluators, produces precise strength measurements, and is easily moved between examining rooms.
INTRODUCTION: Strength measures with reduced variability and higher sensitivity could improve efficiency in clinical trials of amyotrophic lateral sclerosis (ALS). The Accurate Test of Limb Isometric Strength (ATLIS) was developed to precisely and conveniently measure force in 12 muscle groups. In this study we evaluate the reliability and validity of the ATLIS testing protocol. METHODS: Twenty healthy adults and 10 patients with ALS were tested twice by the same or by different evaluators to determine test-retest and interrater reliability. Twenty healthy adults were examined using ATLIS and a well-validated strength testing protocol (TQNE) to assess criterion-based validity. RESULTS: Mean absolute variation between tests was 8.6%, and intraclass correlation coefficients for each muscle group were high (range 0.82-0.99). The Pearson correlation coefficient of mean ATLIS and TQNE scores was 0.90. A subject survey demonstrated high user acceptance of ATLIS. CONCLUSIONS: ATLIS is convenient for patients and evaluators, produces precise strength measurements, and is easily moved between examining rooms.
Authors: Jeremy M Shefner; Seward B Rutkove; James B Caress; Michael Benatar; William S David; Michael S Cartwright; Eric A Macklin; Jose L Bohorquez Journal: Amyotroph Lateral Scler Frontotemporal Degener Date: 2018-09-28 Impact factor: 4.092
Authors: Sabrina Paganoni; Mohamad J Alshikho; Sarah Luppino; James Chan; Lindsay Pothier; David Schoenfeld; Patricia L Andres; Suma Babu; Nicole R Zürcher; Marco L Loggia; Robert L Barry; Silvia Luotti; Giovanni Nardo; Maria Chiara Trolese; Serena Pantalone; Caterina Bendotti; Valentina Bonetto; Fabiola De Marchi; Bruce Rosen; Jacob Hooker; Merit Cudkowicz; Nazem Atassi Journal: Muscle Nerve Date: 2018-12-26 Impact factor: 3.217
Authors: Luis Garcia-Gancedo; Madeline L Kelly; Arseniy Lavrov; Jim Parr; Rob Hart; Rachael Marsden; Martin R Turner; Kevin Talbot; Theresa Chiwera; Christopher E Shaw; Ammar Al-Chalabi Journal: JMIR Mhealth Uhealth Date: 2019-12-20 Impact factor: 4.773