BACKGROUND: The aim of this study was to examine the relationship between nasopharyngeal pneumococcal colonization in early life and the subsequent development of pneumococcal-specific T cell responses. METHODS: Pernasal swabs were collected from Papua New Guinean infants at the ages of 1 and 2 weeks (n = 279). At 9 months, in vitro cellular immune responses to choline-binding protein A (n = 132), pneumococcal surface protein A (n = 132), pneumolysin (n = 99), and the pneumococcal conjugate vaccine carrier CRM197 were determined. Responses were compared based on the children's carriage status within the first 2 weeks of life. RESULTS: Within the first 2 weeks of life, 40% of the study children carried Streptococcus pneumoniae. Early carriage was associated with lower interferon-γ and interleukin 10 responses to pneumococcal proteins at age 9 months when children had not received pneumococcal conjugate vaccines during the study period. CONCLUSIONS: Early pneumococcal carriage may result in enhanced disease susceptibility and suboptimal vaccine responses by modulating the development of pneumococcal immune responses.
BACKGROUND: The aim of this study was to examine the relationship between nasopharyngeal pneumococcal colonization in early life and the subsequent development of pneumococcal-specific T cell responses. METHODS: Pernasal swabs were collected from Papua New Guinean infants at the ages of 1 and 2 weeks (n = 279). At 9 months, in vitro cellular immune responses to choline-binding protein A (n = 132), pneumococcal surface protein A (n = 132), pneumolysin (n = 99), and the pneumococcal conjugate vaccine carrier CRM197 were determined. Responses were compared based on the children's carriage status within the first 2 weeks of life. RESULTS: Within the first 2 weeks of life, 40% of the study children carried Streptococcus pneumoniae. Early carriage was associated with lower interferon-γ and interleukin 10 responses to pneumococcal proteins at age 9 months when children had not received pneumococcal conjugate vaccines during the study period. CONCLUSIONS: Early pneumococcal carriage may result in enhanced disease susceptibility and suboptimal vaccine responses by modulating the development of pneumococcal immune responses.
Authors: David J Dowling; Simon D van Haren; Annette Scheid; Ilana Bergelson; Dhohyung Kim; Christy J Mancuso; Willemina Foppen; Al Ozonoff; Lynn Fresh; Terese B Theriot; Andrew A Lackner; Raina N Fichorova; Dmitri Smirnov; John P Vasilakos; Joe M Beaurline; Mark A Tomai; Cecily C Midkiff; Xavier Alvarez; James L Blanchard; Margaret H Gilbert; Pyone Pyone Aye; Ofer Levy Journal: JCI Insight Date: 2017-03-23
Authors: Holger W Unger; Celestine Aho; Maria Ome-Kaius; Regina A Wangnapi; Alexandra J Umbers; Wanda Jack; Alice Lafana; Audrey Michael; Sarah Hanieh; Peter Siba; Ivo Mueller; Andrew R Greenhill; Stephen J Rogerson Journal: J Clin Microbiol Date: 2015-02-11 Impact factor: 5.948
Authors: J E Navne; M L Børresen; H C Slotved; M Andersson; M Melbye; K Ladefoged; A Koch Journal: Epidemiol Infect Date: 2016-07-13 Impact factor: 4.434
Authors: J P Francis; P C Richmond; D Strickland; S L Prescott; W S Pomat; A Michael; M A Nadal-Sims; C J Edwards-Devitt; P G Holt; D Lehmann; A H J van den Biggelaar Journal: Clin Exp Immunol Date: 2016-12-18 Impact factor: 4.330
Authors: William S Pomat; Anita H J van den Biggelaar; Suparat Phuanukoonnon; Jacinta Francis; Peter Jacoby; Peter M Siba; Michael P Alpers; John C Reeder; Patrick G Holt; Peter C Richmond; Deborah Lehmann Journal: PLoS One Date: 2013-02-22 Impact factor: 3.240