Vincas Urbonas1, Audronė Eidukaitė, Indrė Tamulienė. 1. National Research Institute, Center for Innovative Medicine, Department of Immunology, Moletu pl. 29, LT-08409 Vilnius, Lithuania. vincas.urbonas@santa.lt
Abstract
BACKGROUND: Early diagnosis of bacteremia and sepsis in pediatric oncology patients with febrile neutropenia still remains unresolved task due to lack of sensitive and specific laboratory markers particularly at the beginning of the infectious process. The objective of our study was to assess the potentiality of interleukin-10 (IL-10) to predict or exclude bacteremia or sepsis at the beginning of febrile episode in childhood oncology patients. METHODS: A total of 36 febrile neutropenic episodes in 24 children were studied. Serum samples were collected after confirmation of febrile neutropenia and analyzed using automated random access analyzer. RESULTS: The sensitivity of IL-10 was 73% and specificity - 92% (cut-off=18pg/ml, area under the curve - 0.87, 95% CI for sensitivity 39-94%, 95% CI for specificity 74-99%) with negative predictive value (NPV) - 83%. CONCLUSIONS: IL-10 evaluation might be used as an additional diagnostic tool for clinicians in excluding bacteremia or clinical sepsis in oncology patients with febrile neutropenia because of high NPV and specificity.
BACKGROUND: Early diagnosis of bacteremia and sepsis in pediatric oncology patients with febrile neutropenia still remains unresolved task due to lack of sensitive and specific laboratory markers particularly at the beginning of the infectious process. The objective of our study was to assess the potentiality of interleukin-10 (IL-10) to predict or exclude bacteremia or sepsis at the beginning of febrile episode in childhood oncology patients. METHODS: A total of 36 febrile neutropenic episodes in 24 children were studied. Serum samples were collected after confirmation of febrile neutropenia and analyzed using automated random access analyzer. RESULTS: The sensitivity of IL-10 was 73% and specificity - 92% (cut-off=18pg/ml, area under the curve - 0.87, 95% CI for sensitivity 39-94%, 95% CI for specificity 74-99%) with negative predictive value (NPV) - 83%. CONCLUSIONS:IL-10 evaluation might be used as an additional diagnostic tool for clinicians in excluding bacteremia or clinical sepsis in oncology patients with febrile neutropenia because of high NPV and specificity.
Authors: Luis García de Guadiana-Romualdo; Ignacio Español-Morales; Pablo Cerezuela-Fuentes; Luciano Consuegra-Sánchez; Ana Hernando-Holgado; Patricia Esteban-Torrella; Enrique Jiménez-Santos; Monserrat Viqueira-González; África de Béjar-Almira; María Dolores Albaladejo-Otón Journal: Support Care Cancer Date: 2015-01-07 Impact factor: 3.603
Authors: Andrei E Siniavin; Maria A Streltsova; Denis S Kudryavtsev; Irina V Shelukhina; Yuri N Utkin; Victor I Tsetlin Journal: Biomolecules Date: 2020-03-27